Browsing Dissertations by Author "Rohlik, Denise Lauren"
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Targeting the initiating proteases of the complement system using structure-based small molecule drug discovery
Rohlik, Denise Lauren (East Carolina University, 2023-07-21)The complement system is an essential element of host development and immune homeostasis. This immunoregulatory enzyme cascade is driven by serine protease activation and plays critical roles in the recognition of danger ...