Browsing Dissertations by Subject "Obesity"
Now showing items 1-11 of 11
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THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
(East Carolina University, 2013)The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid ... -
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ... -
EXPLORING THE ROLE OF ELEVATED LIPID PEROXIDATION AND GLUTATHIONE PEROXIDASE 4 IN METABOLIC SYNDROME AND CARDIAC REMODELING IN OBESITY
(5/16/2016)Cardiovascular disease continues to be a leading cause of global mortality. Metabolic perturbations including obesity, hyperlipidemia and type II diabetes arising from a western style diet and a more sedentary lifestyle ... -
IL-15 : A NOVEL REGULATOR OF LIPOLYSIS IN HUMANS?
(East Carolina University, 2014)Interactions between and within organ systems such as skeletal muscle (SkM) and adipose tissue (AT), via immune cell signaling factors (cytokines), may regulate the development of obesity. The increased expression and ... -
Metabolic Inflexibility in Response to Lipid Oversupply with Obesity: Epigenetic Modifications Play a Role
(East Carolina University, 2013)The ability to adjust substrate oxidation according to nutrient availability has been termed `metabolic flexibility' and is a critical factor in overall metabolic health. In respect to fatty acid oxidation (FAO) metabolic ... -
NADPH Oxidase as a Mechanistic Link Between Erectile Dysfunction, Peripheral, and Coronary Endothelial Dysfunction in Obesity
(East Carolina University, 2012)Cardiovascular complications involving both microvascular and macrovascular tissues are the major cause of morbidity and mortality in obese patients. Clinical and epidemiological studies suggest that erectile dysfunction ... -
Quality of life in school-age children with obesity, the experiences of school nurses, and moral distress associated with care delivery
(East Carolina University, 2016-11-16)Childhood obesity is a multifaceted, complex problem that is associated with many other chronic health conditions. School nurses are well positioned to assess, intervene, and evaluate efforts to positively impact this ... -
The Region Specific Influence of Estradiol on In-Vivo Lipolysis in Subcutaneous Adipose Tissue in Overweight-to-Moderately-Obese Premenopausal Women
(East Carolina University, 2012)Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ... -
SKELETAL MUSCLE LIPID PARTITIONING : CONSEQUENCES OF ALTERATIONS IN ACYL-COA SYNTHETASE-5 AND DIGLYCERIDE ACYLTRANFERASE-1 EXPRESSION
(East Carolina University, 2011)An oversupply of fatty acids and inadequacies in their partitioning toward oxidation and/or storage will lead to disruptions in cellular homeostasis. Reductions in mitochondrial content and lower rates of fatty acid ... -
SKELETAL MUSCLE METABOLIC FLEXIBILITY IMPAIRMENTS IN RESPONSE TO LIPID WITH OBESITY : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ... -
The Influence of Diet-Induced Obesity and N-3 Fatty Acids on the Cardiac Mitochondrial Phospholipidome and Respiratory Activity
(East Carolina University, 2017-08-16)Cardiac mitochondrial phospholipids, notably cardiolipin (CL), regulate inner mitochondrial membrane (IMM) organization and protein function, particularly the enzymes associated with respiration. In a range of metabolic ...