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Investigation of the Zinc binding region of Prothymosin-alpha : A spectroscopic and thermodynamic approach to study metal binding in Intrinsically disordered proteins
(East Carolina University, 2014)
The goal of this study is to provide a deeper insight into how metals bind intrinsically disordered proteins (IDPs) by taking zinc binding to prothymosin-alpha as a case study. The involvement of metals in several diseases ...
Targeting the mitochondrial inner membrane to improve bioenergetics in the diseased heart
(East Carolina University, 2014)
Cardiovascular diseases continue to exact unparalleled economic and humanitarian costs across the globe. Manifestations of cardiovascular diseases include acute coronary syndromes and heart failure, both of which are ...
A descriptive exploratory study on how nurse educators use digital stories in the classroom
(East Carolina University, 2014)
This study examines the experiences of 12 nurse educators using digital stories in undergraduate nursing courses. Two issues were explored: 1) How and for what purpose are nurse educators incorporating digital stories in ...
Fundamental and Applied Studies on Chromatographic Separation of Cold Drugs and Skincare Creams and Extraction of Salvia miltiorrhiza using Subcritical Water
(East Carolina University, 2014)
Subcritical water chromatography (SBWC) and subcritical water extraction (SBWE) are two green techniques that use subcritical water as the sole solvent for separations, thus eliminating the use of toxic and expensive organic ...
Transcriptional regulation of 'pqsR', a gene that encodes a regulator of quinolone signal synthesis and virulence in 'Pseudomonas aeruginosa'
(East Carolina University, 2015)
The gram-negative bacterium 'Pseudomonas aeruginosa' is an opportunistic pathogen that frequently causes nosocomial infections and serious chronic lung infections in cystic fibrosis patients. During infection 'P. aeruginosa' ...
N-3 polyunsaturated fatty acids differentially enhance B-cell mediated immunity in lean and obese mice
(East Carolina University, 2014)
Docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) are
bioactive n-3 polyunsaturated fatty acids (PUFAs) in fish oil that
exert immunomodulatory effects. The general paradigm suggests n-3
PUFAs exert immunosuppressive ...
Pragmatic Feminist Empiricism: An Original Analytical Framework for Technical Communication
(East Carolina University, 2017-04-19)
Focusing on issues of embodiment and power in technical communication specifically through visual discourses of health and medicine created through data, the research is an introduction to an original methodology called ...
Integral Captions and Subtitles: Designing a Space for Embodied Rhetorics and Visual Access
(East Carolina University, 2017-04-28)
This dissertation challenges the conventions of adding static captions to the bottom of videos and instead advocates for designing integral captions and integral subtitles that interact with bodies, sound, and other modes ...
Herstory : exploration of the lived experiences of women who were first to lead an HBCU 1994 to 2014
(East Carolina University, 2017-05-04)
There is increasing scrutiny and accountability being placed on colleges and university in American higher education. Historically black colleges and universities are not exempt from that scrutiny, and in some regards may ...
SUGAR HIGH: PSYCHOSOCIAL FACTORS OF PATIENTS WITH TYPE 2 DIABETES IN AN INTEGRATED CARE SETTING
(East Carolina University, 2017-05-03)
Type 2 diabetes (T2D) places considerable strain on patients, their families, and the healthcare system. To promote improved outcomes, it is necessary to assess psychosocial factors that impede or enhance T2D self-management. ...