Search
Now showing items 411-420 of 654
THE PRO-INFLAMMATORY ROLE OF G-PROTEIN COUPLED RECEPTOR 4 IN AN ACIDIC MICROENVIRONMENT
(East Carolina University, 2018-07-20)
The endothelium of the microvascular system serves an ideal mediator between circulating blood and tissues in order to regulate systemic homeostasis. During vascular disease, the normal function and phenotype of endothelial ...
Memetic Rhetorical Theory in Technical Communication: Re-Constructing Ethos in the Post-Fact Era
(East Carolina University, 2018-07-20)
This dissertation interrogates existing interpretations of ethos by analyzing the spread of misinformation through online communities. In particular, this dissertation argues that the rhetorical concept of ethos should ...
Environmental Development of the External Genitalia
(East Carolina University, 2018-07-24)
Hypospadias is one of the most common birth defects in the world. The incidence of hypospadias has nearly doubled over the past 50 years and now occurs on average in 1 in 125 male newborns each year. Hypospadias is a ...
Fast Carbon-Ion and Proton Induced Electron Emission from Condensed-Phase Biological Targets
(East Carolina University, 2018-07-23)
Fast charged particles interact with matter through various ionization and excitation pathways that aren't fully understood. Predicting the effects of these interactions is vital in many fields such as radiation therapy, ...
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)
Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ...
Multidimensional Conceptualization and Assessment of Fatigue in Pediatric Sickle Cell Disease: Impact of Fatigue on Quality of Life
(East Carolina University, 2018-07-20)
Fatigue is a problematic symptom that has only recently gained attention in the literature for pediatric sickle cell disease (SCD). Research has established that fatigue is prevalent, persistent, and impairing, though much ...
Elucidating the Mechanisms of Transthyretin Aggregation in Transthyretin Amyloidosis
(East Carolina University, 2018-07-24)
Accumulation of insoluble aggregates (amyloids) is a characteristic feature of many neurodegenerative diseases including Alzheimer's disease and Parkinson's disease. Aggregation and deposition of Transthyretin (TTR) protein ...
FAMILY DEMENTIA CAREGIVERS’ PERCEPTIONS OF THE VIRTUAL DEMENTIA TOUR®: A CHANGED REALITY
(East Carolina University, 2018-11-27)
Family dementia caregiving involves many challenges that often lead to stress and frustration. A subjective understanding of the daily struggles associated with dementia is not possible unless one has the disease; therefore, ...
THE ROLE OF THE ALVEOLAR MACROPHAGE IN CARBON NANOTUBE ELICITED MURINE MODEL OF PULMONARY GRANULOMATOUS INFLAMMATION
(East Carolina University, 2018-11-29)
Pulmonary sarcoidosis is a debilitating inflammatory condition characterized by the presence of granulomatous lesions throughout the lung. Granulomas are a physiological response to inhaled antigens or particulate matter ...
THE CREATION OF THE ARMADILLO CAREER READINESS SKILLS GAP PROGRAM AT RANDOLPH COMMUNITY COLLEGE: CLOSING THE CAREER GAP FOR HIGH SCHOOL JUNIORS
(East Carolina University, 2018-10-01)
The task of making important career decisions for many individuals and especially high school students occur during high school and beyond. Preparing students to be ready for work, life, and citizenship will require a ...