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Now showing items 481-490 of 654
The effect of concurrent alcohol, drug, psychiatric and vocational treatment on consumer issues, treatment participation, and employment
(East Carolina University, 2013)
Despite high rates of unemployment among individuals with substance use disorders (SUDs) with psychiatric issues, little is known about a substance abuse intensive outpatient program (SAIOP) based on vocational counseling ...
Molecular characterization of the activation domain of the HTLV-1 HBZ protein and its interaction with the KIX domain of the cellular transcriptional coactivators p300 and CBP
(East Carolina University, 2010)
The complex retrovirus human T-cell leukemia virus type I (HTLV-1) is the causative agent of adult T-cell leukemia (ATL). Deregulation of cellular transcription is thought to be a key event in virally-mediated T-cell ...
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)
Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ...
A Biopsychosocial Examination of Transcatheter Aortic Valve Replacement Health Outcomes
(East Carolina University, 2015)
Cardiovascular disease (CVD) is the leading cause of death in the world accounting for 17.3 million deaths annually. Transcatheter aortic valve replacement (TAVR) was developed 13 years ago to treat people suffering from ...
Novel diagnostic and analytical applications of benchtop time-domain NMR.
(East Carolina University, 2015)
High-resolution nuclear magnetic resonance (NMR) spectroscopy is a powerful technique, yet practical application outside of the research laboratory has been limited due to the high cost and complexity of the instrumentation. ...
Hierarchies and Communication : Analyzing Negotiated Power Relationships in a Small Software Company
(East Carolina University, 2013)
This dissertation examines chatroom data gathered over the course of approximately five months at a small software organization to determine whether the power hierarchy in such organizations diverges from the org chart ...
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle
(East Carolina University, 2013)
Effects of obesity on the transcriptional regulation of protein degradation in skeletal muscle by Lance M. Bollinger November, 2013 Director of Thesis/Dissertation: Jeffrey J. Brault Major Department: Kinesiology ...
The Brucella abortus alkyl hydroperoxide reductase complex (AhpCD) is the primary scavenger of endogenous hydrogen peroxide and the ahpCD operon is regulated in response to endogenous hydrogen peroxide.
(East Carolina University, 2010)
Brucella abortus is a facultative intracellular pathogen that causes abortion and infertility in cattle and relapsing fever in humans. These bacteria reside and replicate inside macrophages during infection, and the ability ...
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)
Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...
Improving Medication Adherence In Patients With Multiple Chronic Conditions : Evaluation Of A Pilot Intervention In A Rural Primary Care Clinic
(East Carolina University, 2015)
Background: More than 25% of primary care patients are managing multiple chronic conditions (MCC) and 50% of their medications are not taken as prescribed. Self-efficacy is the foundation of many successful medication ...