Browsing Master's Theses by Title
Now showing items 1861-1880 of 3787
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Investigating the role of CRL5, an ubiquitin ligase, in ovarian follicle development.
(East Carolina University, 2016-07-20)During oogenesis, follicle cells surround maturing oocytes, which produce factors necessary for proper oocyte growth and development. Correct encapsulation of the oocyte by follicle cells is therefore essential for ... -
Investigating the Role of Poxvirus Virulence Genes A35 and O1L in the Virus Life Cycle
(East Carolina University, 2019-07-22)Poxviruses, some of the largest viruses in existence, have a great impact on the human and animal world due to their ability to infect a broad assortment of organisms and cause significant disease. Today, poxvirus infections ... -
Investigating the role of soil legacy effects and community engagement in the management of Lespedeza cuneata, an invasive legume
(East Carolina University, 2020-11-23)Invasive plant species present a growing threat to biodiversity. Many invasive plants are able to recruit microbial symbionts in their novel range and establish plant-soil feedbacks that influence growth and fitness. These ... -
Investigating the role of transcription factor, Trl, during germline development in the Drosophila ovary
(East Carolina University, 2019-07-22)Oogenesis is the process by which an egg develops from undifferentiated cells in the ovary. The Drosophila melanogaster ovary is an assembly line for egg production, making it a great system to investigate initial oocyte ... -
Investigating the Safety Challenges of Unmanned Aerial Vehicles (UAVs) in the Construction Environment
(East Carolina University, 2021-12-01)The technologies associated with Unmanned Aerial vehicles (UAVs) have revolutionized the construction industry, simultaneously demanding a comprehensive understanding of the underlying safety implications in order to reduce ... -
INVESTIGATING THE STAR SCHEMA BENCHMARK AS A REPLACEMENT FOR THE TPC-H DECISION SUPPORT SYSTEM
(East Carolina University, 2016-12-13)Decision Support System (DSS) are at the core of business intelligence systems. Implementation costs for enterprise level Database Management System (DBMS) and DSS average $10,461 for installation costs. This does not ... -
Investigating the Structural and Functional Roles of Conserved Cysteine Residues in Arabidopsis thaliana Fatty-Acid Desaturase 2
(East Carolina University, 2022-12-06)Plant-generated unsaturated fatty acids (UFAs) and polyunsaturated fatty acids (PUFAs) are vital to a plant's growth and survival through maintenance of plasma membrane fluidity and integrity, in addition to the various ... -
Investigation Into The Scope, Limitations, And Mechanistic Aspects Of A Regioselective Acylation Of Cycloplatinated Complexes
(East Carolina University, 2015)In the reaction of N-isopropyl-N-phenyl-2,2'-bipyridin-6-amine with potassium tetrachloroplatinate, the selective C-H bond activation was complicated by the low selectivity of sp² C-H bond activation in acetonitrile and ... -
Investigation of Curli-Specific Proteins CsgD and CsgA Reveals a Potential Target for Neurodegenerative Therapeutics and Provides Structural Insights into the Bacterial Amyloid CsgA
(East Carolina University, 2022-12-06)A growing body of evidence implicates curli-containing biofilms in the onset of neurodegenerative pathologies like Alzheimer's and Parkinson's diseases. Curli-containing biofilms are composed primarily of two bacterial ... -
Investigation of Molecular Mechanism of Transthyretin Oligomerization Associated with ATTR Amyloidosis
(East Carolina University, 2022-04-27)Transthyretin amyloidosis (ATTR) has classically been diagnosed predominantly post-observation of amyloid fibril deposition on soft tissues within the body, however, recent studies have shown that oligomers which arise ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
(East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ... -
Investigation of NADPH-Dependent Thioredoxin Reductase-C (NTRC) In Chloroplast Lipid Metabolism
(East Carolina University, 2022-07-01)Redox reactions are ubiquitous within plant metabolism and critical for the sustainment of photosynthesis within thylakoid membranes. Specialized glycerolipids that make up these membranes in turn require redox reactions ... -
Investigation of Nonhydrolyzable ATP Analogues and Cofilin-Derived Peptides for Inhibition of Cofilin-Actin Rod Formation
(East Carolina University, 2021-08-02)Actin-Cofilin rods are an important marker of neurodegenerative disease and are commonly observed in the neurons of patients with Alzheimer's disease. The goal of this research is to investigate peptide and small-molecules ... -
Investigation of Platinum-Catalyzed Acylation of 2-Aryloxypyridines via C-H Activation and Functionalization
(East Carolina University, 2022-07-12)Transition metal catalyzed C-H activation and functionalization reactions allow synthetic chemists to break the normally unreactive carbon-hydrogen bond and create a new and useful carbon-oxygen, carbon-nitrogen, carbon-halogen, ... -
Investigation of Platinum-Catalyzed Acylation of 2-Aryloxypyridines via C-H Activation and Functionalization
(East Carolina University, 2022-07-12)Transition metal catalyzed C-H activation and functionalization reactions allow synthetic chemists to break the normally unreactive carbon-hydrogen bond and create a new and useful carbon-oxygen, carbon-nitrogen, carbon-halogen, ... -
Investigation of possible driving forces on counter-intuitive thermal collapse of intrinsically disordered proteins
(East Carolina University, 2016-08-18)Intrinsically disordered proteins are an emerging class of proteins that contain no secondary or tertiary structure. Through bioinformatics studies it has been predicted that a third of the human proteome consists of ... -
Investigation of Safety Culture among Young Workers
(East Carolina University, 2019-04-30)According to the Occupational Safety and Health Administration (OSHA), young workers whose ages range from 14 to 24 and are interested in finding different jobs during the summer or during the school year are considered ... -
AN INVESTIGATION OF THE TAPHONOMIC EFFECTS OF ANIMAL SCAVENGING
(East Carolina University, 2014)Numerous environmental and human-induced variables that affect decomposition can cloud accurate estimations of the postmortem interval (PMI). For instance, scavenging animals can remove soft tissue and disarticulate and ...