Browsing Master's Theses by Title
Now showing items 3486-3505 of 3787
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Theoretical Probe to the Mechanism of Pt-catalyzed C-H Acylation Reaction: Possible Pathways for the Key Acylation Reaction of Platinacycles
(East Carolina University, 2019-08-23)Transition metal-catalyzed C-H bond functionalization offers a variety of desirable transformations of simple hydrocarbons to more complex compounds with applications being applied in pharmaceuticals to material sciences. ... -
Theoretical studies on the Annexin A1-S100A11 Heterotetramer and Platinum-Mediated C-H Activation Pathways
(East Carolina University, 2023-07-13)Computational chemistry is a powerful tool for characterizing chemical phenomena when they are difficult to observe in laboratory settings or simply elusive. By employing the fundamental equations of nature, computational ... -
There Has Never Been Anything Truly Wrong with You
(East Carolina University, 2011)These stories are about obsessive, lonely people. The characters might seem insane but really, they are just lonely and maybe a bit neurotic. They are introspective characters who began life as sweet children, but grew ... -
"There Never Was a Good War or a Bad Peace" : Benjamin Franklin's diplomacy and the 1783 Treaty of Paris
(East Carolina University, 2014)This thesis is an analysis of Benjamin Franklin's actions and motivations as he negotiated the 1783 Treaty of Paris on behalf of the newly created United States. It examines three distinct phases beginning with Franklin's ... -
There’s No Place like Aztlán: The Quest for Queer Homeland through Re-visionism in Chicana Feminist Autohistorias
(East Carolina University, 2019-05-02)In this thesis, I explore how authors Gloria Anzaldúa, Cherríe Moraga, Helena María Viramontes, Ana Castillo, Alicia Gaspar de Alba, Sandra Cisneros, Lorna Dee Cervantes, Carla Trujillo and Felicia Luna Lemus represent ... -
Thermodynamic and spectroscopic studies of Cd²⁺ binding to the regulatory domain and full length human cardiac troponin C (HcTnC) : elucidating plausible Cd²⁺ binding sites
(East Carolina University, 2015)Toxic metals such as cadmium (Cd²⁺) have been shown to bind to and interfere with various calcium (Ca²⁺) binding proteins including the regulatory protein cardiac troponin C (cTnC). Recent structural data has shown that ... -
Thermodynamic and Structural Characterization of Cd(II) binding to human cardiac troponin C: Using Mutants and Truncated Constructs to Elucidate Cd(II) binding sites
(East Carolina University, 8/5/2020)Many biological processes rely on the presence of essential metals; therefore, maintaining the concentration of metals is paramount to homeostasis. Cadmium, Cd(II), is a toxic heavy metal that can disturb this delicate ... -
Thermodynamic Investigation into the Binding Properties of Cardiac Troponin (Human and Bovine)
(East Carolina University, 2010)Troponin is an integral protein in the mechanism of muscle contraction. In order to induce cardiac muscle contraction, Ca[superscript]2[superscript]+ must bind to the TnC subunit (calcium binding subunit) of troponin to ... -
Thermodynamic Investigation of Copper Binding to the Amyloid-Beta (A[beta]) Peptide
(East Carolina University, 2010)Alzheimer's disease is a fatal and neurodegenerative disease with as many as 5.3 million Americans living with the disease. One of the characteristic hallmarks of Alzheimer's is the amyloid plaques that build up around the ... -
Thermodynamic Investigations into Copper Binding in the N-Terminal Region of the Prion Protein at Low Copper Loadings
(East Carolina University, 2010)The prion protein (PrP) is a naturally occurring protein found at high levels in central nervous system (CNS). The misfolding of the PrP is responsible for neurodegenerative diseases called transmissible spongioform ... -
Thermodynamic studies of Ca²⁺ binding to human cardiac troponin C
(East Carolina University, 2012)Human Cardiac Troponin C (HcTnC) is an EF hand protein responsible for initiating contraction of the myocardium (heart muscle). The helix-loop-helix motif, characteristic of members of the EF-hand family, allows HcTnC to ... -
Thesis - generating knowledgebase of common behavior and workflow patterns for secure systems
(East Carolina University, 2018-05-02)Knowledge discovery from large data for system security management and threat detection have been a complex task due to large number of users and the dynamic nature of distributed systems. Healthcare organizations as a ... -
"They Would Have a Law of Their Own" : The Discourse on Smuggling at the Old Bailey, 1736-1814
(East Carolina University, 2013)This thesis examines the cases of 136 men tried for smuggling offenses at London's central criminal court during the long eighteenth century. Before the 1770s, the government portrayed smuggling as a crime against the ... -
The Things We Hear in the Nighttime & Other Stories
(East Carolina University, 2015)THE THINGS WE HEAR IN THE NIGHTTIME & OTHER STORIES is a collection of five short stories and five pieces of flash fiction. The writing in the collection focuses on the ever-changing American identity of the 20th and 21st ... -
Thoughts on Temporal Perception's Relativity in Grisey's Vortex Temporum and Voss's Perspectives
(East Carolina University, 2017-07-21)This thesis centers around a comparative analysis between an instrumental work, Vortex Temporum (1995), by Gérard Grisey (1946-98), and a mixed media work by Emerson Voss (b. 1991), Perspectives (2017). This essay articulates ... -
Threat Modelling and Analysis of Web Application Attacks
(East Carolina University, 2018-12-12)There has been a rapid growth in the use of the Internet over the years with billions of businesses using it as a means of communication. The World Wide Web has served as the major tool for disseminating information which ...