Browsing Master's Theses by Subject "Molecular biology"
Now showing items 21-40 of 44
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A Functional Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2012)MicroRNAs (miRNAs) are a newly discovered class of endogenous post-transcriptional gene regulators that are typically 20-22 nucleotides in length that do not code for proteins. MiRNAs regulate gene expression by either ... -
Genome-Wide Identification And Expression Analysis Of TCP Transcription Factors In Cotton
(East Carolina University, 2015)TCP proteins are plant-specific transcription factors known to perform a variety of physiological functions during plant growth and development. In the current study, we performed for the first time the comprehensive ... -
Hox Gene Expression During Oreochromis niloticus Pharyngeal Arch Development : Discovering the Hox Code
(East Carolina University, 2010)Hox genes encode transcription factors and have been extensively studied by evolutionary and developmental biologists. Hox genes are responsible for determining specific regional identities along the anterior-posterior and ... -
Identification, Characterization, and Abiotic Stress Analysis of microRNAs in Nicotiana tabacum
(East Carolina University, 2010)microRNAs (miRNAs) are non-coding RNAs with short sequences that negatively regulate gene expression at the post-transcriptional levels by either binding to mRNAs for degradation, or by inhibiting protein translation. ... -
Interaction and Functional Analysis of Drosophila Mcm10
(East Carolina University, 2010)In eukaryotic cells, DNA replication and the subsequent packaging of DNA into specific chromatin states are essential processes for the transmission of genetic material and genomic stability which may be linked by interactions ... -
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ... -
LOCALIZATION AND CHANGES OF NUCLEAR PROGESTERONE RECEPTORS IN ZEBRAFISH OOCYTES AND ADJACENT FOLLICULAR CELLS
(East Carolina University, 2010)The nuclear progesterone receptor (Pgr) is one of the major mediators for progestin signaling during oocyte ovulation in vertebrates. However, any roles Pgr may play in oocyte growth, and especially in the final oocyte ... -
Molecular Epidemiology of MRSA Among Patients and Employees in a Surgical Intensive Care Unit
(East Carolina University, 2011)Methicillin-resistant Staphylococcus aureus (MRSA) is a pervasive drug resistant human pathogen and has become widespread in hospitals around the world. MRSA infections cause approximately 19,000 deaths among hospitalized ... -
Neurological Effects Of A Single Low Level Blast Overpressure Exposure : Behavior And Micro RNA Mechanisms Of Mild Traumatic Brain Injury In A Rodent Model
(East Carolina University, 2015)The increased use of explosive devices within warfare and acts of terrorism has allowed blast overpressure exposure (BOE) to become a significant concern. The most common wound sustained by BOE is blast-induced mild traumatic ... -
Phylogenetics and Systematics of the Millipede genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae)
(East Carolina University, 2010)The genus Brachycybe Wood, 1864 (Platydesmida: Andrognathidae) belongs to an ancient millipede lineage that has persisted since the Miocene. The group displays a Holarctic distribution with species in the eastern Nearctic, ... -
Physiological Studies of Alkaliphilic Anaerobic Organotrophs in a Serpentinizing Subsurface Habitat
(East Carolina University, 2014)Microbial habitats in serpentinizing ultramafic rocks represent one of the largest, yet least understood portions of the biosphere, with potentially major consequences for global biogeochemical cycles. Serpentinization is ... -
Proposed regulatory role of noncatalytic Adams in ectodomain shedding
(East Carolina University, 2015)Members of the ADAM (A Disintegrin And Metalloprotease) protein family uniquely exhibit both proteolytic and adhesive properties. Specifically, ADAMs catalyze the conversion of cell-surface proteins to soluble, biologically ... -
Psf2, a member of the heterotetrameric GINS Complex, plays a role in cell cycle progression and maintenance of genomic integrity
(East Carolina University, 2010)Multiple proteins are involved in the complete and accurate replication of the genome during S phase of the cell cycle. At the G1/S phase transition, the heterotetrameric GINS complex is recruited to the origin, and ... -
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells
(East Carolina University, 2012)The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ... -
The Role of GSK-3[beta] in MCF-7 Breast Cancer Cell Signaling and Drug Resistance
(East Carolina University, 2011)Glycogen synthase kinase- 3beta (GSK-3beta) is well documented to participate in a complex array of critical cellular processes. This versatile protein is involved in numerous signaling pathways that influence metabolism, ... -
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
The Role of Transcription Factors Snail and Slug in Cardiac Myofibroblasts
(East Carolina University, 2014)CCardiac fibrosis is a major facet contributing to cardiac dysfunction following a myocardial infarction. Persistent and excessive collagen deposition via cardiac myofibroblasts is the hallmark of cardiac fibrosis. Cardiac ... -
Sld5, A Subunit of the Heterotetrameric GINS Complex is Necessary for Normal Cell Cycle Progression and Genomic Stability
(East Carolina University, 2010)Sld5 is one component of the GINS heterotetrameric complex essential to DNA replication. Specifically, GINS is known for its integral role during the G1 to S phase transition in the cell cycle. The GINS complex is comprised ... -
SPATIAL EXPRESSION OF MATRIX AND MATRIX RECEPTOR PROTEINS IN THE DEVELOPING SYNOVIAL JOINT
(East Carolina University, 2013)Little is understood about the complex spatial and temporal molecular interactions necessary to form a fully functional synovial joint. Understanding molecular pathways and signaling within the developing joint continues ... -
SYNAPTOPODIN-2 ISOFORM A AND D EXPRESSION IN HT-29 HUMAN COLON ADENOCARCINOMA CELLS
(East Carolina University, 2013)Synaptopodin-2 is a largely unfolded actin-binding protein that also possesses the characteristics of a hub protein. Synaptopodin-2 has other known binding partners such as filamin and [alpha]-actinin (Weins, et al. 2001 ...