Browsing Master's Theses by Author "Thomassen, Mary Jane"
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Expression of microRNA in Alveolar Macrophages Deficient in PPARy
McPeek, Matthew (East Carolina University, 2014)The nuclear transcription factor Peroxisome proliferator-activated receptor gamma (PPARgamma) is a negative regulator of macrophage activation and inflammatory mediators. Alveolar macrophages of healthy individuals ... -
Resolution of Chronic Granulomatous Inflammation and Fibrosis in a Murine Model of Sarcoidosis
Bhalla, Sophia (East Carolina University, 2021-07-14)Sarcoidosis is a chronic granulomatous disease of unknown cause. Granulomas resolve within 12-26 months in 50% of cases without therapy while 30% of patients have chronic disease that progresses to pulmonary fibrosis. The ... -
Role of Macrophage Polarization and Apolipoprotein E in Granuloma Resolution
Ogburn, David R (East Carolina University, 2021-07-06)Sarcoidosis is a chronic disease characterized by the development and accumulation of granulomas. Through multiwall carbon nanotube (MWCNT) instillation of C57 Bl/6 (wild-type) mice, we have established a murine model that ...