Browsing Master's Theses by Subject "Insulin resistance"
Now showing items 1-9 of 9
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Blood Lactate Predicts Resting Energy Expenditure in Non-Obese Caucasian Females
(East Carolina University, 2019-08-01)Background: Obesity and Type 2 Diabetes are both global epidemics that continue to skyrocket. High basal plasma lactate levels, reduced oxidative capacity, and insulin resistance are co-morbidities with these metabolic ... -
Deletion of LPCAT3 Promotes Enhanced Insulin Signaling in Skeletal Muscle
(East Carolina University, 2015-12-15)Aberrant lipid metabolism has been linked to skeletal muscle insulin resistance. The exact identity of the lipid species that promote skeletal muscle insulin resistance among the human population remains unclear. In this ... -
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
(East Carolina University, 2009)A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ... -
Effect of Exercise Training on Metabolic Syndrome z-score : the Association of C- reactive protein
(East Carolina University, 2015-06-25)PURPOSE: Previous studies have shown that metabolic syndrome z-score (MetSynZ) is improved with exercise training. Metabolic syndrome is based upon insulin resistance, such that it would be expected for insulin resistance ... -
EFFECT OF MENTOR-LED VIGOROUS AEROBIC EXERCISE PROGRAM ON BODY COMPOSITION, PEAK VO₂, AND INSULIN SENSITIVITY IN OVERWEIGHT AND OBESE ADOLESCENTS
(East Carolina University, 2014)In the past few decades obesity rates in the US have reached epidemic proportions in both adults and children. Nearly one-third of American adults are obese, and since 1980, the obesity rates for children 6-11 years and ... -
Mitochondrial Oxidative Capacity In Human Skeletal Muscle: Association with Plasma Lactate Concentration
(East Carolina University, 2018-07-11)ABSTRACT Background: Metabolic disease is a growing concern for public health. Obesity and Type II Diabetes are an epidemic and a phenotype for insulin resistance in human skeletal muscle. A reduced mitochondrial function ... -
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ... -
A single dose of metformin improves whole body insulin sensitivity and alters cellular redox state in skeletal muscle of Zucker fa/fa rats
(East Carolina University, 2010)Energy balance is considered a fundamental requirement of life forms from single cell organisms to higher mammals such as humans. Unfortunately, our species has also discovered the detrimental metabolic responses to excess ... -
The Effects of the OPTIFAST Diet and Aerobic Exercise on Insulin Sensitivity
(East Carolina University, 2022-04-21)BACKGROUND: Clinical weight loss (CWL) (5-10%) combined with aerobic exercise improves insulin sensitivity. The OPTIFAST program is a medically supervised diet for weight loss, however, there is minimal data available on ...