Browsing Master's Theses by Subject "Mice"
Now showing items 1-9 of 9
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30-Day Immunotoxicity Study of PFMOAA in C57BL/6 Mice
(East Carolina University, 2019-07-18)Within the past five years, two classes of per- and polyfluoroalkyl substances (PFAS) were phased out of production in the U.S., which led to the development and production of PFAS to replace these two major classes. One ... -
The contribution of motility and chemotaxis in the Borrelia burgdorferi infectious life cycle
(East Carolina University, 2013)Lyme disease has emerged as an increasing problem for people in the east and northeastern part of the United States. It can cause a chronic debilitating infection if left untreated and is difficult to diagnose. The illness ... -
Dopaminergic modulation of the autonomic nervous system: in vitro and in vivo evidence from the mouse
(East Carolina University, 2012)Central nervous system (CNS) function depends on both the connections between the underlying neurons and neural circuits and their activity. Neuronal activity in turn can be classified as neurotransmission and neuromodulation, ... -
Effects of PFMOAA, An Understudied PFAS, on Developing Mice
(East Carolina University, 2021-08-16)Perfluoro-2-methoxyaacetic acid (PFMOAA) was recently the most prevalent emerging per- and polyfluoroalkyl substance (PFAS) detected in the Cape Fear River of North Carolina (NC). A byproduct of fluorochemical manufacturing, ... -
Matrix Metalloproteinase 12 is Critical for Granuloma Formation in the Murine Model of Granulomatous disease
(East Carolina University, 2019-08-16)Matrix Metalloproteinase 12 (MMP12) is a protein produced primarily by alveolar macrophages that degrades elastin in the extracellular matrix (ECM) and enables infiltration of immune cells that participate in the inflammatory ... -
Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized Molecular Histology of EphrinA1 Expression in Mouse Heart Visualized with MALDI-MSI
(East Carolina University, 2018-07-25)EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ... -
Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ... -
Resolution of Chronic Granulomatous Inflammation and Fibrosis in a Murine Model of Sarcoidosis
(East Carolina University, 2021-07-14)Sarcoidosis is a chronic granulomatous disease of unknown cause. Granulomas resolve within 12-26 months in 50% of cases without therapy while 30% of patients have chronic disease that progresses to pulmonary fibrosis. The ... -
THE EFFECT OF AMP DEAMINASE 3 DEFICIENCY ON POST-MYOCARDIAL INFARCT FUNCTIONAL AND HISTOLOGICAL OUTCOMES IN MICE
(East Carolina University, 2019-07-17)PURPOSE: Humans deficient in the metabolic enzyme AMP deaminase 3 have improved survival and clinical outcomes in cases of revascularization, myocardial infarction, and/or heart failure. Because of the nature of this ...