Browsing Master's Theses by Subject "Muscular atrophy"
Now showing items 1-7 of 7
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AMP Deaminase 3 knockout mice and loss of mitochondrial proteins and enzyme activity during denervation atrophy
(East Carolina University, 2018-07-17)Muscle atrophy leads to decrements in muscle function, partly attributable to decreased mitochondrial content. One controller of mitochondrial content is AMP-activated protein kinase (AMPK), which when bound by AMP activates ... -
CaMKII Protein Expression and Phosphorylation in Mouse Skeletal Muscle Following Atrophy and Hypertrophy
(East Carolina University, 2012)The maintenance of skeletal muscle mass is vital for life, and elucidation of the molecular mechanisms that control this process is a critical first step towards the development of pharmaceutical treatments for muscle ... -
High-Fat Diet Induced Obesity Increases Serum Myostatin, but Does Not Accelerate Skeletal Muscle Atrophy
(East Carolina University, 2013)Myostatin is a potent negative regulator of muscle mass, i.e. high levels of myostatin induce loss of muscle. Surprisingly, severely obese humans and obese mice have elevated levels of serum myostatin, but the role of ... -
Increased Antagonist Coactivation-Related Hamstring Torque Reduces Maximal Knee Extension Torque in Healthy Old Adults
(East Carolina University, 2010)As humans age, the ability to produce maximal voluntary torque decreases due to muscle atrophy (sarcopenia) and it is also known that advancing age alters the neural control of voluntary movement. One manifestation of the ... -
Increased Degradation of Adenosine Monophosphate as a Regulator of Maximal Mitochondrial Respiration
(East Carolina University, 2019-07-02)Atrophied skeletal muscle have enhanced fatigability due at least in part to a reduction of mitochondria content. Mitochondrial biogenesis is regulated by the transcriptional coactivator PGC-1 alpha, which in turn is ... -
Mouse Strain Dependent Differences in Muscle Fiber Type, Fiber Area, and Blood Perfusion in Response to Denervation Atrophy
(East Carolina University, 1/13/16)Skeletal muscle atrophy caused by denervation is a serious consequence of neuropathic disease, especially diabetes. However, the only proven treatment for muscle atrophy is exercise, which can be difficult or impossible ... -
Paired Effects of Dietary Leucine Supplementation and Overload on Protein Translational Signaling and Hypertrophy in Aged Rat Skeletal Muscle
(East Carolina University, 2012)Sarcopenia is an age-associated disorder that causes loss of skeletal muscle mass, particularly in type II (fast-twitch) muscle fibers. This loss in muscle mass can cause disability, reductions in the quality of life, and ...