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Transthyretin Amyloidosis: Proteolytic cleavage accelerates G53A TTR misfolding and aggregation
(East Carolina University, 2020-06-22)
The proteolytic cleavage of the peptide bond Lys48-Thr49 of the CD loop in TTR pathological mutants S52P and E51_S52dup was previously demonstrated to promote aggregation as a result of tetrameric structure destabilization. ...
MVC EDUCATION 3D : A FRAMEWORK FOR DISTANCE EDUCATION VIRTUAL REALITY APPLICATIONS
(East Carolina University, 2020-06-22)
Recent advancements in the online course delivery for Distance Education(DE) pro- gram is evolving from day-to-day. Though DE programs cost less and also provide exibility to students depending on their pace of learning, ...
DEFINING THE STRATIGRAPHIC AND PALEOENVIRONMENTAL RECORD OF RAPID SEA-LEVEL RISE DURING THE LATE PLEISTOCENE TO HOLOCENE IN THE ALBEMARLE SOUND REGION OF NORTH CAROLINA
(East Carolina University, 2022-08-19)
We need to replace the abstract.
LONG-TERM FERTILIZATION AND SOIL MOISTURE INTERACT TO INFLUENCE PLANT AND BACTERIAL COMMUNITIES IN A LOW NUTRIENT WETLAND
(East Carolina University, 2022-12-20)
Human activities such as urbanization and intensive agriculture modify nutrient and water cycles in significant ways. Changes to nutrient and water cycles can cause disruptions to plant-microbe mutualisms, especially in ...
Effects of Childhood Chronic Illness on Depression Outcomes in Adulthood
(East Carolina University, 2022-12-06)
The present study evaluated the impacts of a chronic illness diagnosis in childhood on long-term depression levels in adulthood. Additionally, this study sought to determine whether the age at which a diagnosis was received ...
Characterizing the Role of Pectin in Cell Wall Composition and Organ Initiation in Maize
(East Carolina University, 2022-12-07)
Plants are constantly developing new organs throughout their life and these organs arise from stem cell pools called meristems. Organ primordia are generated on the flanks of meristems when stem cells differentiate into ...
Slate Graffiti
(East Carolina University, 2022-12-06)
Although sometimes the subject of scholarly and artistic publication, the complexity of vanishing cultures in Appalachia often defies exposition. The elusive identities of the inhabitants are articulated within this ...
A Patient-Specific Multiscale Model of Mechanical Ventilation of COVID-19-afflicted Lungs
(East Carolina University, 2022-07-24)
Coronavirus disease-2019 (COVID-19) is a respiratory disease that caused a worldwide pandemic and, in some cases, manifests as an acute respiratory distress syndrome. Severe cases of COVID-19 are often treated with mechanical ...
Investigating the Relationship Between Zetaproteobacteria and Cyanobacteria and its Implications for the Geological Record
(East Carolina University, 2022-07-14)
Banded Iron Formations (BIFs) are geological relics of the ancient oceans that were partially formed by microorganisms. This includes oxygenic phototrophs and iron-oxidizing bacteria (FeOB) whose relative contributions are ...
Reinforcement Learning based Recommender System using Q-Learning and Deep Q-Learning
(East Carolina University, 2022-07-14)
The first part of this thesis concludes with an overall summary of the publications so far on the recommender system using reinforcement learning. We have performed a systematic review of the research studies published ...