Search
Now showing items 1-10 of 42
Investigating the Interaction of RecQL4 and Mcm10 in Drosophila melanogaster
(East Carolina University, 2014)
Accurate duplication and regulation of the eukaryotic genome requires precise coordination among multiple replication factors. RecQL4, the least characterized RecQ protein, is a 1208 amino acid protein containing a centrally ...
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)
Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ...
Analysis of Myopodin in Hela Cervical Carcinoma Cells
(East Carolina University, 2014)
Synaptopodin-2 is a proline-rich, actin-binding protein that exists in many isoforms. Due to its large proline content, synaptopodin-2 exists in a naturally unfolded state and possesses the characteristics of a hub protein. ...
Analysis of scn5Laa and scn5Lab Gene Function in Danio rerio (Zebrafish) Heart Development through TALENs/CRISPR-CAS9-mediated Gene Knockout
(East Carolina University, 2015)
Research in our laboratory is focused on understanding the molecular developmental genetic effects of crude oil exposure on vertebrate embryogenesis. Our research has demonstrated that exposure of zebrafish embryos to ...
Genome-Wide Identification And Expression Analysis Of TCP Transcription Factors In Cotton
(East Carolina University, 2015)
TCP proteins are plant-specific transcription factors known to perform a variety of physiological functions during plant growth and development. In the current study, we performed for the first time the comprehensive ...
Neurological Effects Of A Single Low Level Blast Overpressure Exposure : Behavior And Micro RNA Mechanisms Of Mild Traumatic Brain Injury In A Rodent Model
(East Carolina University, 2015)
The increased use of explosive devices within warfare and acts of terrorism has allowed blast overpressure exposure (BOE) to become a significant concern. The most common wound sustained by BOE is blast-induced mild traumatic ...
Proposed regulatory role of noncatalytic Adams in ectodomain shedding
(East Carolina University, 2015)
Members of the ADAM (A Disintegrin And Metalloprotease) protein family uniquely exhibit both proteolytic and adhesive properties. Specifically, ADAMs catalyze the conversion of cell-surface proteins to soluble, biologically ...
The contribution of motility and chemotaxis in the Borrelia burgdorferi infectious life cycle
(East Carolina University, 2013)
Lyme disease has emerged as an increasing problem for people in the east and northeastern part of the United States. It can cause a chronic debilitating infection if left untreated and is difficult to diagnose. The illness ...
SPATIAL EXPRESSION OF MATRIX AND MATRIX RECEPTOR PROTEINS IN THE DEVELOPING SYNOVIAL JOINT
(East Carolina University, 2013)
Little is understood about the complex spatial and temporal molecular interactions necessary to form a fully functional synovial joint. Understanding molecular pathways and signaling within the developing joint continues ...
Comparison of ZnO nanoparticles and ZnCl₂ induced germ cell apoptosis in Caenorhabditis elegans
(East Carolina University, 2014)
There is inadequate research data available on manufactured ZnO nanoparticles. Manufactured nanoparticles are widely used in various products and production of manufactured nanoparticles is becoming increasingly abundant. ...