Browsing Kinesiology by Author "Neufer, P. Darrell"
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Diet-Induced Muscle Insulin Resistance Is Associated With Extracellular Matrix Remodeling and Interaction With Integrin αβ in Mice
Kang, Li; Ayala, Julio E.; Lee-Young, Robert S.; Zhang, Zhonghua; James, Freyja D.; Neufer, P. Darrell; Pozzi, Ambra; Zutter, Mary M.; Wasserman, David H. (2011-02) -
Effect of Acute Exercise or Fasting on Mitochondrial Function and High Fat Diet-Induced Insulin Resistance
Kwon, Oh Sung (East Carolina University, 2009)A high-fat diet leads to an accumulation of lipid in skeletal muscle, and the development of both mitochondrial dysfunction and insulin resistance. Recently, our lab reported that lipid overload leads to elevated ... -
Effects of Insulin Sensitivity Modulators on the Mitochondrial Fate of Oxygen in Skeletal Muscle
Kane, Daniel A. (East Carolina University, 2010)Increasingly, reactive oxygen species (ROS) are implicated in the development of insulin resistance. To test the hypothesis that modulators of insulin sensitivity (i.e., metformin, ovarian sex steroids and exercise training) ... -
The effects of statins on mitochondrial function
Mayo, William Joseph (East Carolina University, 2013)Statins, or 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductase inhibitors, are among the most commonly prescribed medications in the United States. They are commonly used to treat hypercholesterolemia, a condition ... -
ESTABLISHMENT OF THE PYRUVATE DEHYDROGENASE COMPLEX AS A CENTRAL REGULATOR OF MITOCHONDRIAL REDOX WITHIN SKELETAL MUSCLE
Fisher-Wellman, Kelsey H. (East Carolina University, 2013)Once regarded as "byproducts" of aerobic metabolism, the production of superoxide/H₂O₂ is now understood to be a highly specialized and extensively regulated process responsible for exerting control over a vast number of ... -
Heterozygous SOD2 Deletion Impairs Glucose-Stimulated Insulin Secretion, but Not Insulin Action, in High-Fat–Fed Mice
Kang, Li; Dai, Chunhua; Lustig, Mary E.; Bonner, Jeffrey S.; Mayes, Wesley H.; Mokshagundam, Shilpa; James, Freyja D.; Thompson, Courtney S.; Lin, Chien-Te; Perry, Christopher G.R.; Anderson, Ethan; Neufer, P. Darrell; Wasserman, David H.; Powers, Alvin C. (2014-11) -
The Influence of Energy Expenditure on Mitochondrial Functions, Oxidative Stress and Insulin Resistance under Metabolic Oversupply Conditions
Lin, Chien-Te (East Carolina University, 2011)Mitochondrial respiratory capacity and oxidative stress have been implicated in the development of insulin resistance (IR) and type II diabetes. A causative role of mitochondrial oxidative stress in the etiology of ... -
NOVEL MECHANISMS GOVERNING SKELETAL MUSCLE MITOCHONDRIAL BIOENERGETICS : OXPHOS EFFICIENCY AND cAMP/PKA SIGNALING
Lark, Daniel Stephen (East Carolina University, 2014)Understanding the regulation of cellular metabolism is paramount to treating the growing prevalence of metabolic disease worldwide. In cellular metabolism, mitochondrial oxidative phosphorylation (OXPHOS) plays a key role ... -
A single dose of metformin improves whole body insulin sensitivity and alters cellular redox state in skeletal muscle of Zucker fa/fa rats
Lark, Daniel Stephen (East Carolina University, 2010)Energy balance is considered a fundamental requirement of life forms from single cell organisms to higher mammals such as humans. Unfortunately, our species has also discovered the detrimental metabolic responses to excess ... -
Transcriptional regulation of muscle fatty acid-binding protein.
Carey, Julie O.; Neufer, P. Darrell; Farrar, Roger P.; Veerkamp, Jacques H.; Dohm, G. Lynis (East Carolina University, 1994-03-15)Heart fatty acid-binding protein (H-FABP) is present in a wide variety of tissues but is found in the highest concentration in cardiac and red skeletal muscle. It has been proposed that the expression of H-FABP correlates ... -
Unravelling the mechanisms of menopause-induced insulin resistance: novel roles for estradiol in skeletal muscle mitochondrial function
Torres, Maria Jose (East Carolina University, 2016-11-16)Menopause results in a progressive decline in ovarian production of 17[beta]-estradiol (E2), increased adiposity and a higher risk for type-2 diabetes, but hormone replacement therapies containing E2 reverse most of these ...