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Review of microdialysis in brain tumors, from concept to application: First Annual Carolyn Frye-Halloran Symposium
(East Carolina University, 2004-01)
In individuals with brain tumors, pharmacodynamic and pharmacokinetic studies of therapeutic agents have historically used analyses of drug concentrations in serum or cerebrospinal fluid, which unfortunately do not necessarily ...
VARIABILITY IN POPLITEAL ARTERY BLOOD FLOW : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)
Mean arterial pressure (MAP) is regulated through changes in cardiac output (Q) and total peripheral resistance (TPR), where Q = heart rate (HR) x stroke volume (SV). Healthy heart rhythms have inherent variability and a ...
The Effects of Quadriceps Strengthening Exercise on Quadriceps Muscle Biomechanics During Locomotion in Adults with Knee Osteoarthritis
(East Carolina University, 2013)
Knee Osteoarthritis (OA) is a disease characterized by knee joint deterioration and pain, while also being associated with altered knee joint mechanics and quadriceps strength deficits. Research investigating the effects ...
SKELETAL MUSCLE METABOLIC FLEXIBILITY IMPAIRMENTS IN RESPONSE TO LIPID WITH OBESITY : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)
Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...
Proximal vs. Distal Fascicle Behavior within the Biceps Femoris Long Head at Different Muscle Activation Levels
(East Carolina University, 2013)
Hamstring strains have been shown to occur more often in the long head of the biceps femoris (BFLH) than the semitendinosus and semimembranosus, with most injuries occurring in the proximal half of the BFLH. Muscle modeling ...
Paired Effects of Dietary Leucine Supplementation and Overload on Protein Translational Signaling and Hypertrophy in Aged Rat Skeletal Muscle
(East Carolina University, 2012)
Sarcopenia is an age-associated disorder that causes loss of skeletal muscle mass, particularly in type II (fast-twitch) muscle fibers. This loss in muscle mass can cause disability, reductions in the quality of life, and ...
The Region Specific Influence of Estradiol on In-Vivo Lipolysis in Subcutaneous Adipose Tissue in Overweight-to-Moderately-Obese Premenopausal Women
(East Carolina University, 2012)
Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ...
The relationship between visual steadiness and force steadiness in young and old adults
(East Carolina University, 2013)
Old adults exhibit a decrease in muscle force steadiness and visual capability compared to young adults. Many studies investigating force steadiness have used a visual target as the stimulus for modulating muscle force. ...
Assessing Children's Physical Activity in Their Homes: The Observational System for Recording Physical Activity in Children-Home
(East Carolina University, 2009)
The present study describes the development and pilot testing of the Observation System for Recording Physical Activity in Children-Home version. This system was developed to document physical activity and related physical ...
EFFECT OF A TELEPHONE-BASED INTERVENTION ON PHYSICAL ACTIVITY AND COMPONENTS OF THE METABOLIC SYNDROME IN ADOLESCENTS
(East Carolina University, 2013)
The purpose of this study was to determine the effects of a two month telephone-based intervention in obese adolescents (BMI percentile [greater than or equal to] 95th percentile) on physical activity habits and motivation ...