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Now showing items 11-17 of 17
Effects of High-Insulin Exposure on Mitochondrial Content in Skeletal Muscle Myotubes from Lean & Severely Obese Individuals: A Time Course Analysis
(East Carolina University, 2016-08-01)
Skeletal muscle is the site at which highly regulated energetic processes take place as a means of maintaining both tissue-specific and whole-body metabolism. With the development of severe obesity (BMI [greater-than] or ...
Short-term, high-fat diet accelerates disuse atrophy and protein degradation in a muscle-specific manner in mice
(2015-11-04)
Background:
A short-term high-fat diet impairs mitochondrial function and the ability of skeletal muscle to respond to growth stimuli, but it is unknown whether such a diet alters the ability to respond to atrophy signals. ...
The Relationship between Gait Biomechanics and Body Mass Index
(East Carolina University, 2014)
Walking gait is one of the basic components of human movements. With the rising obesity epidemic and implied health complications, it is pertinent to examine the relationship between body mass index and the joint torques ...
SKELETAL MUSCLE METABOLIC FLEXIBILITY IMPAIRMENTS IN RESPONSE TO LIPID WITH OBESITY : EFFECT OF EXERCISE TRAINING
(East Carolina University, 2012)
Obese individuals exhibit skeletal muscle metabolic inflexibility by failing to increase fat oxidation and genes linked with mitochondrial biogenesis in response to a high-fat diet (HFD) and lipid incubation in cell culture. ...
The Region Specific Influence of Estradiol on In-Vivo Lipolysis in Subcutaneous Adipose Tissue in Overweight-to-Moderately-Obese Premenopausal Women
(East Carolina University, 2012)
Premenopausal women demonstrate preferential accumulation of adiposity in the gynoid region, a distribution which shifts towards the abdominal region after the menopausal transition. Although estrogen is implicated as a ...
EFFECT OF A TELEPHONE-BASED INTERVENTION ON PHYSICAL ACTIVITY AND COMPONENTS OF THE METABOLIC SYNDROME IN ADOLESCENTS
(East Carolina University, 2013)
The purpose of this study was to determine the effects of a two month telephone-based intervention in obese adolescents (BMI percentile [greater than or equal to] 95th percentile) on physical activity habits and motivation ...
THE EFFECT OF CONTRACTILE ACTIVITY AND SUBSTRATE CHALLENGES ON METABOLIC FLEXIBILITY IN HUMAN PRIMARY MYOTUBES
(East Carolina University, 2013)
The skeletal muscle of severely obese individuals (BMI > 40 kg/m²) is characterized by a depressed ability to oxidize fatty acids and a failure to upregulate fatty acid oxidation (FAO) in response to increased lipid ...