Construct validity of a continuous metabolic syndrome score in children
Author
Eisenmann, Joey C.; Laurson, Kelly R.; DuBose, Katrina D.; Smith, Bryan K.; Donnelly, Joseph E.
Abstract
Objective: The primary purpose of this study was to examine the construct validity of a continuous metabolic syndrome score (cMetS) in children. The secondary purpose was to identify a cutpoint value(s) for an adverse cMetS based on receiver operating characteristic (ROC) curve analysis. Methods: 378 children aged 7 to 9 years were assessed for the metabolic syndrome which was determined by
age-modified cutpoints. High-density-lipoprotein cholesterol, triglycerides, the homeostasis assessment model of insulin resistance, mean arterial pressure, and waist circumference were used to create a cMetS for each subject. Results: About half of the subjects did not possess any risk factors while about 5% possessed the metabolic
syndrome. There was a graded relationship between the cMetS and the number of adverse risk factors. The cMetS was lowest in the group with no adverse risk factors (-1.59 ± 1.76) and highest in those possessing the metabolic syndrome (≥3 risk factors) (7.05 ± 2.73). The cutoff level yielding the maximal sensitivity and specificity for predicting the presence of the metabolic syndrome was a cMetS of 3.72 (sensitivity = 100%, specificity = 93.9%,
and the area of the curve = 0.978 (0.957-0.990, 95% confidence intervals). Conclusion: The results demonstrate the construct validity for the cMetS in children. Since there are several drawbacks to identifying a single cut-point value for the cMetS based on this sample, we urge researchers to use the approach herein to validate and create a cMetS that is specific to their study population. Originally published Diabetology and Metabolic Syndrome, Vol. 2, No. 8, Jan 2010
Date
2010-01-28
Citation:
APA:
Eisenmann, Joey C., & Laurson, Kelly R., & DuBose, Katrina D., & Smith, Bryan K., & Donnelly, Joseph E.. (January 2010).
Construct validity of a continuous metabolic syndrome score in children.
Diabetology and Metabolic Syndrome,
2(1),
-
. Retrieved from
http://hdl.handle.net/10342/3256
MLA:
Eisenmann, Joey C., and Laurson, Kelly R., and DuBose, Katrina D., and Smith, Bryan K., and Donnelly, Joseph E..
"Construct validity of a continuous metabolic syndrome score in children". Diabetology and Metabolic Syndrome.
2:1. (8),
January 2010.
March 19, 2024.
http://hdl.handle.net/10342/3256.
Chicago:
Eisenmann, Joey C. and Laurson, Kelly R. and DuBose, Katrina D. and Smith, Bryan K. and Donnelly, Joseph E.,
"Construct validity of a continuous metabolic syndrome score in children," Diabetology and Metabolic Syndrome 2, no.
1 (January 2010),
http://hdl.handle.net/10342/3256 (accessed
March 19, 2024).
AMA:
Eisenmann, Joey C., Laurson, Kelly R., DuBose, Katrina D., Smith, Bryan K., Donnelly, Joseph E..
Construct validity of a continuous metabolic syndrome score in children. Diabetology and Metabolic Syndrome.
January 2010;
2(1):
8.
http://hdl.handle.net/10342/3256. Accessed
March 19, 2024.
Collections
Publisher
East Carolina University