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Insertional activation of cepA leads to high-level beta-lactamase expression in Bacteroides fragilis clinical isolates.
(East Carolina University, 1994-07)
Bacteroides fragilis is an important opportunistic pathogen of humans and is resistant to many drugs commonly used to treat anaerobic infections, including P-lactams. A strain set comprised of B. fragilis isolates producing ...
The nucleotide sequence of the Pseudomonas aeruginosa pyrE-crc-rph region and the purification of the crc gene product.
(East Carolina University, 1996-10)
The gene (crc) responsible for catabolite repression control in Pseudomonas aeruginosa has been cloned and sequenced. Flanking the crc gene are genes encoding orotate phosphoribosyl transferase (pyrE) and RNase PH (rph). ...
Thioredoxin Reductase Is Essential for Thiol/Disulfide Redox Control and Oxidative Stress Survival of the Anaerobe Bacteroides fragilis
(East Carolina University, 2007-11)
Results of this study showed that the anaerobic, opportunistic pathogen Bacteroides fragilis lacks the
glutathione/glutaredoxin redox system and possesses an extensive number of putative thioredoxin (Trx)
orthologs. ...
Nucleotide sequence of the phosphoprotein (P) gene of Newcastle disease virus (strain Beaudette C).
(East Carolina University, 1992-02)
Cecal and fecal bacterial flora of the Mongolian gerbil and the chinchilla.
(East Carolina University, 1988-05)
The Mongolian gerbil is being increasingly used as a laboratory animal and as a pet. Both chinchillas and gerbils are used as animal models for otitis media and other otic research. Previously, only incomplete information ...
Invasion and Intracellular Survival of Burkholderia cepacia
(East Carolina University, 2000-01)
Burkholderia cepacia has emerged as an important pulmonary pathogen in immunocompromised patients
and in patients with cystic fibrosis (CF). Little is known about the virulence factors and pathogenesis of B.
cepacia, ...
Production of the Siderophore 2,3-Dihydroxybenzoic Acid Is Required for Wild-Type Growth of Brucella abortus in the Presence of Erythritol under Low-Iron Conditions In Vitro
(East Carolina University, 2003-05)
Production of the siderophore 2,3-dihyroxybenzoic acid (2,3-DHBA) is required for the wild-type virulence of Brucella abortus in cattle. A possible explanation for this requirement was uncovered when it was determined that ...
Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance
(East Carolina University, 2007-08)
Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ...
Targeting the leukemic stem cell: the Holy Grail of leukemia therapy
(East Carolina University, 2009-01)
Since the discovery of leukemic stem cells (LSCs) over a decade ago, many of their critical biological
properties have been elucidated, including their distinct replicative properties, cell surface
phenotypes, their ...
Analysis of rRNA restriction fragment length polymorphisms from Bacteroides spp. and Bacteroides fragilis isolates associated with diarrhea in humans and animals.
(East Carolina University, 1992-04)
The Escherichia coli rRNA operon rrnB was used as a 32P-labeled hybridization probe in Southern blots of
genomic DNAs from representative strains of the saccharolytic, gram-negative, obligate anaerobes of the genus
Bacteroides. ...