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The 52nd Annual Wind River Conference on Prokaryotic Biology -- 2008
(East Carolina University, 2008-12)
Base-By-Base: Single nucleotide-level analysis of whole viral genome alignments
(East Carolina University, 2004-07-14)
Background: With ever increasing numbers of closely related virus genomes being sequenced, it has become desirable to be able to compare two genomes at a level more detailed than gene content because two strains of an ...
Autocrine production of extracellular catalase prevents apoptosis of the human CEM T-cell line in serum-free medium.
(East Carolina University, 1993-05-15)
CCRF-CEM is a human T-cell line originally isolated from a child with acute lymphoblastic leukemia. At cell densities > 2 x 10 cells per ml, CEM cells grow in serum-free medium, but at lower cell densities the cultures ...
The Brucella abortus Cu,Zn Superoxide Dismutase Is Required for Optimal Resistance to Oxidative Killing by Murine Macrophages and Wild-Type Virulence in Experimentally Infected Mice
(East Carolina University, 2005-05)
Two-dimensional gel electrophoretic analysis of cell lysates from Brucella abortus 2308 and the isogenic hfq mutant Hfq3 revealed that the RNA binding protein Hfq (also known as host factor I or HF-I) is required for the ...
Using death to one's advantage: HIV modulation of apoptosis
(East Carolina University, 2001-03)
Infection by human immunodeficiency virus (HIV) is associated with an early immune dysfunction and progressive destruction of CD4+ T lymphocytes. This progressive disappearance of T cells leads to a lack of immune control ...
PI3K activation is associated with intracellular sodium/iodide symporter protein expression in breast cancer
(East Carolina University, 2007-07-25)
Background: The sodium/iodide symporter (NIS) is a membrane glycoprotein mediating active iodide uptake in the thyroid gland and is the molecular basis for radioiodide imaging and therapeutic ablation of thyroid carcinomas. ...
Interference with Pseudomonas quinolone signal synthesis inhibits virulence factor expression by Pseudomonas aeruginosa
(East Carolina University, 2001-09-25)
Pseudomonas aeruginosa is an opportunistic pathogen that controls numerous virulence factors through intercellular signals. This bacterium has two quorum-sensing systems (las and rhl), which act through the intercellular ...
Cytokines and neuroantigens for treatment of immune disorders
(2017-05-10)
The present invention provides methods of regulating an immunological disorder comprising administering to a subject an effective amount of (i) an autoimmune antigen in conjunction with (ii) an anti-inflammatory cytokine. ...
Hox-gene expression as a biomarker for igf-1r therapeutics
(2008-09-25)
This invention provides methods for treating or preventing the onset of a tumor in a subject, wherein the tumor is determined to overexpress a Hox gene, including administering to the subject a therapeutically or ...
Attenuated viruses and method of making the same
(1996-04-18)
Disclosed are attenuated viruses, not naturally occurring, that contain one or more additional methylation sites in the genome of the virus compared to the corresponding wild-type virus. Preferably, the methylation sites ...