Browsing Biology by Title
Now showing items 105-124 of 1310
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Analysis of Myopodin in Hela Cervical Carcinoma Cells
(East Carolina University, 2014)Synaptopodin-2 is a proline-rich, actin-binding protein that exists in many isoforms. Due to its large proline content, synaptopodin-2 exists in a naturally unfolded state and possesses the characteristics of a hub protein. ... -
Analysis of scn5Laa and scn5Lab Gene Function in Danio rerio (Zebrafish) Heart Development through TALENs/CRISPR-CAS9-mediated Gene Knockout
(East Carolina University, 2015)Research in our laboratory is focused on understanding the molecular developmental genetic effects of crude oil exposure on vertebrate embryogenesis. Our research has demonstrated that exposure of zebrafish embryos to ... -
Analysis of the hex regulon in Pseudomonas aeruginosa
(East Carolina University, 2012)Pseudomonas aeruginosa is an opportunistic pathogen whose defense mechanisms include biofilm production through carbohydrate metabolism. The activity of the enzymes in the hex regulon are required for catabolism of glucose ... -
Analysis of the Maize dicer-like1 Mutant, fuzzy tassel, Implicates MicroRNAs in Anther Maturation and Dehiscence
(2016-01-08)Sexual reproduction in plants requires development of haploid gametophytes from somatic tissues. Pollen is the male gametophyte and develops within the stamen; defects in the somatic tissues of the stamen and in the male ... -
Analysis of the miR319 target Zmtcptf24 in the maize inflorescence
(2014-12)Maize inflorescences are essential for reproduction and also produce seeds that are consumed as food. To understand the genetics pathways that control normal inflorescence development, we study mutants with abnormal ... -
Ancient gene transfer from algae to animals: Mechanisms and evolutionary significance
(2012)Background Horizontal gene transfer (HGT) is traditionally considered to be rare in multicellular eukaryotes such as animals. Recently, many genes of miscellaneous algal origins were discovered in choanoflagellates. ... -
Ancient Genome Duplications Did Not Structure the Human Hox-Bearing Chromosomes
(East Carolina University, 2001-05)The fact that there are four homeobox (Hox) clusters in most vertebrates but only one in invertebrates is often cited as evidence for the hypothesis that two rounds of genome duplication by polyploidization occurred early ... -
Androgen and progesterone receptor knockouts in Danio rerio affect aggression and social dominance (part 1)
(East Carolina University, 2018-12-07)It is well known that competition for the basic resources of food, shelter, and mates will always exist in nature. The most prevalent method of competing for such resources is aggression and social dominance. There is ... -
ANDROGEN AND PROGESTERONE RECEPTORS KNOCKOUTS IN ZEBRAFISH AFFECT AGGRESSION AND SOCIAL DOMINANCE
(East Carolina University, 2019-05-03)ABSTRACT - There is circumstantial evidence that steroids, such as androgens and progesterone, play roles in aggression and social behaviors in vertebrates. However, the genetic basis for these behaviors needs to be further ... -
Anti-Cancer Activity of Cucurbitacin IIa
(East Carolina University, 2012)Cancer is a debilitating disease resulting from uncontrolled proliferation. One major treatment strategy for cancer is the application of chemotherapeutic drugs which kill cancer cells. Cucurbitacins are a new family ... -
The AraC-Like Transcriptional Regulator DhbR Is Required for Maximum Expression of the 2,3-Dihydroxybenzoic Acid Biosynthesis Genes in Brucella abortus 2308 in Response to Iron Deprivation
(East Carolina University, 2008-03)Phenotypic evaluation of isogenic mutants derived from Brucella abortus 2308 indicates that the AlcR homolog DhbR (2,3-dihydroxybenzoic acid [2,3-DHBA] biosynthesis regulator) modulates the expression of the genes involved ... -
Are algal genes in nonphotosynthetic protists evidence of historical plastid endosymbioses?
(East Carolina University, 2009)Background: How photosynthetic organelles, or plastids, were acquired by diverse eukaryotes is among the most hotly debated topics in broad scale eukaryotic evolution. The history of plastid endosymbioses commonly is ... -
ARE ALL FISH NURSERIES EQUAL? DETERMINING HOW FOOD WEB DYNAMICS AFFECT FISH NURSERY HABITAT
(East Carolina University, 2018-07-23)The fish nursery habitat concept has been used to define important habitat for larval and juvenile fish throughout coastal and estuarine areas. Nursery habitat has been defined as an area that produces more fish biomass, ... -
Are All Parasitic Infections Created Equal? An Examination of Differential Infection Effects and Responses in Native and Non-Native Hosts
(East Carolina University, 2018-12-10)Interactions between native and introduced species are complex, multifaceted, and can have cascading effects throughout an ecosystem. While scientists have taken great strides to understand how these dynamics change with ...