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TOXICITY OF METAL OXIDE NANOPARTICLES TO CAENORHABDITIS ELEGANS
(East Carolina University, 2012)
The increase in manufacturing and use of nanoparticles is expected to elevate levels of exposure to humans and other organisms. Presently, there is little understanding of the potential toxic effects of nanoparticle exposure. ...
Analysis of the hex regulon in Pseudomonas aeruginosa
(East Carolina University, 2012)
Pseudomonas aeruginosa is an opportunistic pathogen whose defense mechanisms include biofilm production through carbohydrate metabolism. The activity of the enzymes in the hex regulon are required for catabolism of glucose ...
The Role of eIF4G-1 Isoforms and Live Cell Imaging of IRES-mediated Translation Initiation in Breast Cancer Cells
(East Carolina University, 2012)
The development of cancer is a consequence of mutations that lead to dysfunctional cell processes such as unrestrained cell proliferation, resistance to apoptosis, and improper regulation of cell processes such as translation. ...
Cryptic Seed Heteromorphism in Packera tomentosa (Asteraceae) : Differences in Seed Mass Characteristics and Germination
(East Carolina University, 2012)
Germination requirements of seeds can dictate when and where plant offspring establish. Microsites available for germination vary spatially and temporally in factors such as temperature and moisture; thus, the production ...
Local and Regional Aspects of Habitat Quality Jointly Affect the Biodiversity of Ephemeral Ponds
(East Carolina University, 2012)
The biodiversity of local communities is likely affected by both local habitat quality and by the quality of the landscape surrounding the locality. In pond environments, habitat quality may be affected by the kind of leaf ...
VALIDATION OF CANDIDATE GENES IN RESPONSE TO VERSICAN MANIPULATION IN DEVELOPING SYNOVIAL JOINTS
(East Carolina University, 2012)
Little is understood about the complex process of synovial joint formation in early limb development. It has been shown that versican is highly expressed in the extracellular matrix of these joints (Snow et al., 2005; ...
Drosophila Psf2 Has a Role In Chromosome Condensation
(East Carolina University, 2012)
The condensation state of chromosomes is a critical parameter in multiple processes within the cell. Failures in the maintenance of appropriate condensation states may lead to genomic instability, mis-expression of genes, ...
The effects of environmental nickel toxicity upon survival, growth, reproduction, fecundity, and lifespan of nematodes Caenorhabditis elegans, Pristionchus pacificus, and Caenorhabditis briggsae
(East Carolina University, 2012)
Nickel (II) is a common component of many natural products and man-made devices. Due to its frequent use in everyday life, relatively large amounts of nickel are being released into the environment. Nickel, however, is a ...
Consequences of Reduced Versican Expression in Embryonic Chick Synovial Joint Development
(East Carolina University, 2012)
The different mechanisms involved in vertebrate synovial joint development are actively being uncovered. A variety of studies have thus far discovered the involvement of several large molecules in the processes of joint ...
ESTABLISHING LINKAGE BETWEEN GINS COMPLEX SUB-UNIT Sld5 AND CHECKPOINT PROTEIN Chk2 (loki) USING DROSOPHILA MELANOGASTER AS MODEL ORGANISM
(East Carolina University, 2012)
Eukaryotic DNA replication is controlled by a number of proteins that ensures the process takes place accurately. GINS, a hetero-tetrameric protein complex is known to be essential for the initiation and progression of ...