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Mutations and deregulation of Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mtor cascades which alter therapy response
(2012-09-20)
The Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR cascades are often activated by genetic alterations in upstream signaling molecules such as receptor tyrosine kinases (RTK). Certain components of these pathways, RAS, NF1, BRAF, ...
Recent progress in genetics of aging, senescence and longevity: Focusing on cancer-related genes
(2012-12-30)
It is widely believed that aging results from the accumulation of molecular damage, including damage of DNA and mitochondria and accumulation of molecular garbage both inside and outside of the cell. Recently, this paradigm ...
Prospects for the study of evolution in the deep biosphere
(2012)
Since the days of Darwin, scientists have used the framework of the theory of evolution to explore the interconnectedness of life on Earth and adaptation of organisms to the ever-changing environment. The advent of molecular ...
Cytokine-neuroantigen fusion proteins as a new class of tolerogenic, therapeutic vaccines for treatment of inflammatory demyelinating disease in rodent models of multiple sclerosis
(2012-08-20)
Myelin-specific induction of tolerance represents a promising means to modify the course of autoimmune inflammatory demyelinating diseases such as multiple sclerosis (MS). Our laboratory has focused on a novel preclinical ...
Digits lost or gained? Evidence for pedal evolution in the Dwarf salamander complex (Eurycea, Plethodontidae)
(2012-05-23)
Change in digit number, particularly digit loss, has occurred repeatedly over the evolutionary history of tetrapods. Although digit loss has been documented among distantly related species of salamanders, it is relatively ...
Effects of aluminum oxide nanoparticles on the growth, development, and microrna expression of tobacco (nicotiana tabacum)
(2012-05-11)
Nanoparticles are a class of newly emerging environmental pollutions. To date, few experiments have been conducted to investigate the effect nanoparticles may have on plant growth and development. It is important to study ...
Early cell loss associated with mesenchymal stem cell cardiomyoplasty
(2012-03-01)
Background: Human mesenchymal stem cells (hMSCs) show potential for therapeutic cellular cardiomyoplasty. However, a range of delivery methods, including direct intramyocardial injection, have resulted in poor engraftment ...
Correlation of pretreatment drug induced apoptosis in ovarian cancer cells with patient survival and clinical response
(2012-08-08)
This study was performed to determine if a chemotherapy-induced apoptosis assay (MiCK) could predict the best therapy for patients with ovarian cancer. A prospective, multi-institutional and blinded trial of the assay was ...
Landscape influences on fisher success: Adaptation strategies in closed and open access fisheries in southern Chile
(2012-03)
Determinants of fisher success in southern Chile's loco (Concholepas concholepas) fishery are examined by comparing fisher success in exclusive access territories that vary in relationship to tree-plantation development, ...