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The Multifunctional Protein BAG3: A Novel Therapeutic Target in Cardiovascular Disease
(2018-02-26)
The B-cell lymphoma 2–associated anthanogene (BAG3) protein is expressed most prominently in the heart, the skeletal muscle, and in many forms of cancer. In the heart, it serves as a co-chaperone with heat shock proteins ...
The National Clinical Assessment Tool for Medical Students in the Emergency Department (NCAT-EM)
(2018-01)
Introduction: Clinical assessment of medical students in emergency medicine (EM) clerkships is
a highly variable process that presents unique challenges and opportunities. Currently, clerkship directors use institution-specific ...
The Plight of the Minority Resident Physician— Similar Challenges in a Different World
(2018-09-28)
In the article “Minority Resident Physicians’ Views on the Role of Race/Ethnicity in Their Training Experiences in the Workplace,” Osseo-Asare et al1 report a qualitative approach to teasing out the plight of underrepresented ...
Glaucomatous optic disc changes despite normal baseline intraocular pressure in a child
(2018-12-14)
Purpose:
We describe a case of normal tension glaucoma in the setting of sickle cell disease in a 9-year-old patient with a five-year follow up.
Observations:
A 9-year-old male patient with a history of sickle cell ...
Diversity in warning coloration: selective paradox or the norm?
(2018-08-27)
Aposematic theory has historically predicted that predators should select for warning signals to converge on a single form, as a result of frequency‐dependent learning. However, widespread variation in warning signals is ...
Effects of cardiomyopathy-linked mutations K15N and R21H in tropomyosin on thin-filament regulation and pointed-end dynamics
(2018-11-14)
Missense mutations K15N and R21H in striated muscle tropomyosin are linked to dilated cardiomyopathy (DCM) and hypertrophic cardiomyopathy (HCM), respectively. Tropomyosin, together with the troponin complex, regulates ...
Effectiveness of a Total Meal Replacement Program (OPTIFAST Program) on Weight Loss: Results from the OPTIWIN Study
(2018-11-13)
Objective: The aim of this study was to test the effectiveness of the OPTIFAST program (OP), a total meal replacement dietary intervention, compared with a food-based (FB) dietary plan for weight loss. Methods: Participants ...
Therapeutic targeting of CK2 in acute and chronic leukemias
(2018-01)
Phosphorylation can regulate almost every property of a protein and is involved in all fundamental cellular processes. Thus, proper regulation of phosphorylation events is critical to the homeostatic functions of cell ...
TNM cancer staging: can it help develop a novel staging system for type 2 diabetes?
(2018-11-28)
Abstract: Type 2 diabetes (DM2) constitutes 90%–95% of the diabetes cases and is increasing at an alarming rate in the world. The Centers for Disease Control and Prevention (CDC) esti- mates that more than 29 million people ...
Variation in female aggression in 2 three-spined stickleback populations with female throat and spine coloration
(2018-03-07)
Despite growing interest in female ornament evolution, we still have a rudimentary understanding of female display traits relative to similar traits in males. Under one popular adaptive scenario, fe- male ornaments are ...