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Esophageal perforation secondary to malignant gastric outlet obstruction: a case report
(2019-02-19)
Background
Esophageal perforation is a rare presenting sign of gastric cancer. To date, only nine case reports of this phenomenon have been previously published.
Case presentation
Esophageal perforation was diagnosed ...
A system‐based intervention to reduce Black‐White disparities in the treatment of early stage lung cancer: A pragmatic trial at five cancer centers
(2019-01-11)
Background: Advances in early diagnosis and curative treatment have reduced high
mortality rates associated with non‐small cell lung cancer. However, racial disparity
in survival persists partly because Black patients ...
A Waterfront View of Coastal Hazards: Contextualizing Relationships among Geographic Exposure, Shoreline Type, and Hazard Concerns among Coastal Residents
(2019-11-26)
Coastal communities exist on the front lines of diverse natural hazards and the growing
impacts of climate change. While traditional strategies for dealing with coastal hazards have often
involved the hardening or armoring ...
Antivenom Treatment Is Associated with Fewer Patients using Opioids after Copperhead Envenomation
(2019-03-20)
Introduction
Copperhead envenomation causes local tissue destruction, leading people to seek treatment for the pain and swelling. First-line treatment for the pain is opioid medications. There is rising concern that an ...
Abnormal Involuntary Movement Scale in Tardive Dyskinesia:Minimal Clinically Important Difference
(2019-05-27)
Background
A minimal clinically important difference has not been established for the Abnormal Involuntary Movement Scale in patients with tardive dyskinesia. Valbenazine is a vesicular monoamine transporter 2 inhibitor ...
Association of Lowering Low‐Density Lipoprotein Cholesterol With Contemporary Lipid‐Lowering Therapies and Risk of Diabetes Mellitus: A Systematic Review and Meta‐Analysis
(2019-04-02)
Background
The relationship between lowering LDL (low‐density lipoprotein) cholesterol with contemporary lipid‐lowering therapies and incident diabetes mellitus (DM) remains uncertain.
Methods and Results
Thirty‐three ...
Association Between Health Literacy, Electronic Health Literacy, Disease-Specific Knowledge, and Health-Related Quality of Life Among Adults With Chronic Obstructive Pulmonary Disease: Cross-Sectional Study
(2019-06-06)
Background: Despite the relatively high prevalence of low health literacy among individuals living with chronic obstructive pulmonary disease (COPD), limited empirical attention has been paid to the cognitive and health ...
Construction of realistic hybrid computational fetal phantoms from radiological images in three gestational ages for radiation dosimetry applications
(2019-10-10)
Radiation exposure and associated radiation risks are major concerns for fetal development for
pregnant patients who undergo radiation therapy or diagnostic imaging procedures. In order to
accurately estimate the radiation ...
Claudin-7 Modulates Cl− and Na+ Homeostasis and WNK4 Expression in Renal Collecting Duct Cells
(2019-07-30)
Claudin-7 knockout (CLDN7−/−) mice display renal salt wasting and dehydration
phenotypes. To address the role of CLDN7 in kidneys, we established collecting duct (CD) cell
lines from CLDN7+/+ and CLDN7−/− mouse kidneys. ...
Administration of alpha klotho reduces liver and adipose lipid accumulation in obese mice
(2019-04-05)
α-Klotho, a known anti-aging protein, exerts diverse physiological effects including: maintenance of phosphate and calcium homeostasis, modulation of cell proliferation, and enhanced buffering of reactive oxygen species. ...