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Timing of Esophagectomy after Neoadjuvant Chemoradiation Therapy Affects the Incidence of Anastomotic Leaks
(2019-02-05)
Background:
Neoadjuvant chemoradiation therapy (nCRT) has become the standard of care for esophageal cancer patients prior to esophagectomy. However, the optimal timing for surgery after completion of nCRT remains ...
Towards measuring resilience of flood-prone communities: a conceptual framework
(2019-06-17)
Community resilience has become an important
policy and research concept for understanding and addressing the challenges associated with the interplay of climate
change, urbanization, population growth, land use, ...
The validity, reliability and minimal clinically important difference of the patient specific functional scale in snake envenomation
(2019-03-05)
Objective:
Valid, reliable, and clinically relevant outcome measures are necessary in clinical studies of snake envenomation. The aim of this study was to evaluate the psychometric (validity and reliability) and clinimetric ...
The effects of temperature on Bosmina longirostris susceptibility to microcystin-LR acute toxicity
(2019-07-09)
Harmful algal blooms are an ongoing threat to many aquatic systems throughout the world. In the Chowan River, North Carolina, the frequency of toxin producing Microcystis aeruginosa blooms has increased since 1975 along ...
Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
(2019-01-10)
Characterization of small oligomers formed at an early stage of amyloid formation is critical to
understanding molecular mechanism of pathogenic aggregation process. Here we identifed and
characterized cytotoxic oligomeric ...
TOXIFY: a deep learning approach to classify animal venom proteins
(2019-06-28)
In the era of Next-Generation Sequencing and shotgun proteomics, the sequences
of animal toxigenic proteins are being generated at rates exceeding the pace of
traditional means for empirical toxicity verification. To ...
Mitsui-7, heat-treated, and nitrogen-doped multi-walled carbon nanotubes elicit genotoxicity in human lung epithelial cells.
(2019-10-07)
Background:
The unique physicochemical properties of multi-walled carbon nanotubes (MWCNT) have led to many industrial applications. Due to their low density and small size, MWCNT are easily aerosolized in the workplace ...
Kinetics and Identities of Extracellular Peptidases in Subsurface Sediments of the White Oak River Estuary, North Carolina
(2019-09-17)
Anoxic subsurface sediments contain communities of heterotrophic microorganisms that metabolize organic carbon at extraordinarily low rates. In order to assess the mechanisms by which subsurface microorganisms access ...
Mitochondrial PE potentiates respiratory enzymes to amplify skeletal muscle aerobic capacity
(2019-09-11)
Exercise capacity is a strong predictor of all-cause mortality. Skeletal muscle mitochondrial respiratory capacity, its biggest contributor, adapts robustly to changes in energy demands induced by contractile activity. ...
MELPF version 1: Modeling Error Learning based Post-Processor Framework for Hydrologic Models Accuracy Improvement
(2019-09-23)
This paper studies how to improve the accuracy of hydrologic models using machine-learning models as postprocessors and presents possibilities to reduce the workload to create an accurate hydrologic model by removing the ...