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Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
(2015)
Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a ...
Comparison of Whole Blood and Peripheral Blood Mononuclear Cell Gene Expression for Evaluation of the Perioperative Inflammatory Response in Patients with Advanced Heart Failure
(2014-12-17)
Background: Heart failure (HF) prevalence is increasing in the United States.
Mechanical Circulatory Support (MCS) therapy is an option for Advanced HF
(AdHF) patients. Perioperatively, multiorgan dysfunction (MOD) is ...
Spatial and temporal translational control of germ cell mRNAs mediated by the eIF4E isoform IFE-1
(2015)
Regulated mRNA translation is vital for germ cells to produce new
proteins in the spatial and temporal patterns that drive gamete
development. Translational control involves the de-repression of
stored mRNAs and their ...
Interventions to improve sarcopenia in cirrhosis: A systematic review
(2019-01-26)
BACKGROUND:
Sarcopenia, i.e., muscle loss is now a well-recognized complication of cirrhosis and in cases of non-alcoholic fatty liver disease can contribute to accelerate liver fibrosis leading to cirrhosis. Hence, it ...
It’s not what you expect: feedback negativity is independent of reward expectation and affective responsivity in a non-probabilistic task
(2017-03)
ERP studies commonly utilize gambling-based reinforcement tasks to elicit feedback negativity (FN) responses. This study used a pattern learning task in order to limit gambling-related fallacious reasoning and possible ...
MicroRNA expression profiles during cotton (Gossypium hirsutum L) fiber early development
(2017-03-22)
The role of microRNAs (miRNAs) during cotton fiber development remains unclear. Here, a total of
54 miRNAs belonging to 39 families were selected to characterize miRNA regulatory mechanism in eight different fiber development ...
Isolated neutropenia as a rare but serious adverse event secondary to immune checkpoint inhibition
(2019-07-05)
Background
Compared to conventional chemotherapy, Immune checkpoint inhibitors (ICI) are known to have a distinct toxicity profile commonly identified as immune-related adverse events (irAEs). These irAEs that are believed ...
Karyotype analysis and sex determination in Australian Brush-turkeys (Alectura lathami)
(2017-09-14)
Sexual differentiation across taxa may be due to genetic sex determination (GSD) and/or temperature sex determination (TSD). In many mammals, males are heterogametic (XY); whereas females are homogametic (XX). In most ...
Limited indications of tax stamp discordance and counterfeiting on cigarette packs purchased in tobacco retailers, 97 counties, USA, 2012
(2017-09-28)
Increasing the per-unit cost of tobacco products is one of the strongest interventions for tobacco control. In jurisdictions with higher taxes in the U.S., however, cigarette pack litter studies show a substantial proportion ...