Search
Now showing items 841-850 of 991
Obesity in a model of gpx4 haploinsufficiency uncovers a causal role for lipid-derived aldehydes in human metabolic disease and cardiomyopathy
(2015)
Objective: Lipid peroxides and their reactive aldehyde derivatives (LPPs) have been linked to obesity-related pathologies, but whether they have a causal role has remained unclear. Glutathione peroxidase 4 (GPx4) is a ...
Protein Kinase A Governs Oxidative Phosphorylation Kinetics and Oxidant Emitting Potential at Complex I
(2015)
he mitochondrial electron transport system (ETS) is responsible for setting and
maintaining both the energy and redox charges throughout the cell. Reversible
phosphorylation of mitochondrial proteins, particularly via ...
Effects of exercise on obesity-induced mitochondrial dysfunction in skeletal muscle
(2017-11)
Obesity is known to induce inhibition of glucose uptake, reduction of lipid metabolism, and progressive loss of skeletal muscle function, which are all as- sociated with mitochondrial dysfunction in skeletal muscle. ...
Docosahexaenoic acid counteracts palmitate-induced endoplasmic reticulum stress in C2C12 myotubes: Impact on muscle atrophy
(2017-12)
Lipid accumulation in skeletal muscle results in dysregulation of protein meta- bolism and muscle atrophy. We previously reported that treating C2C12 myo- tubes with palmitate (PA), a saturated fatty acid, increases the ...
Differential expression of microRNAs during fiber development between fuzzless- lintless mutant and its wild-type allotetraploid cotton
(2017-01-31)
Cotton is one of the most important textile crops but little is known how microRNAs regulate cotton fiber development. Using a well-studied cotton fiberless mutant Xu-142-fl, we compared 54 miRNAs for their expression ...
Remote Antimicrobial Stewardship in Community Hospitals
(2015-11)
Antimicrobial stewardship has become standard practice at university medical centers, but the practice is more difficult to implement in remote community hospitals that lack infectious diseases trained practitioners. ...
Effect of High-Dose Vitamin C Infusion in a Glucose-6-Phosphate Dehydrogenase-Deficient Patient
(2017-11-26)
Vitamin C supplementation is generally regarded as benign. There has been a resurgence of interest in the general medical community regarding the use of vitamin C most notably in the care of sepsis. Nonetheless, caution ...
Comparison of Whole Blood and Peripheral Blood Mononuclear Cell Gene Expression for Evaluation of the Perioperative Inflammatory Response in Patients with Advanced Heart Failure
(2014-12-17)
Background: Heart failure (HF) prevalence is increasing in the United States.
Mechanical Circulatory Support (MCS) therapy is an option for Advanced HF
(AdHF) patients. Perioperatively, multiorgan dysfunction (MOD) is ...