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PI3K isoform inhibition associated with anti Bcr-Abl drugs shows in vitro increased anti-leukemic activity in Philadelphia chromosome-positive B-acute lymphoblastic leukemia cell lines
(2017-02-20)
B-acute lymphoblastic leukemia (B-ALL) is a malignant disorder characterized by the abnormal proliferation of B-cell progenitors. Philadelphia chromosome-positive (Ph+) B-ALL is a subtype that expresses the Bcr-Abl fusion ...
Molecular targeting of the Aurora-A/SMAD5 oncogenic axis restores chemosensitivity in human breast cancer cells
(2017-09-01)
Although the majority of breast cancers initially respond to the cytotoxic effects of chemotherapeutic agents, most breast cancer patients experience tumor relapse and ultimately die because of drug resistance. Breast ...
Ml proteins from Mesorhizobium loti and MucR from Brucella abortus: an AT-rich core DNA-target site and oligomerization ability
(2017-11-17)
Mesorhizobium loti contains ten genes coding for proteins sharing high amino acid sequence identity with members of the Ros/MucR transcription factor family. Five of these Ros/MucR family members from Mesorhizobium loti ...
Plasma Irisin Modestly Increases during Moderate and High-Intensity Afternoon Exercise in Obese Females
(2017-01-26)
Background and Purpose
Irisin is an exercise-responsive myokine that has been proposed to exert anti-obesity bene- fits; yet its response during exercise in obese women is not described. This study character- ized plasma ...
Pineal Region Glioblastoma, a Case Report and Literature Review
(2017-06-12)
Introduction: Pineal region glioblastoma multiforme (GBM) is a rare disease entity with a generally poor prognosis. We present a case of a patient with an unresectable pineal region GBM treated with chemoradiation with ...
Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
(2017-08-24)
A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative ...
Health effects following subacute exposure to geogenic dust collected from active drainage surfaces (Nellis Dunes Recreation Area, Las Vegas, NV)
(2017-12-08)
The specific health effects of directinhalation of fine minerogenic dusts generated by natural soil surfaces
remain poorly known and relatively little researched. To learn more about this exposure and its contribution
to ...
A 14-year longitudinal study of the impact of clean indoor air legislation on state smoking prevalence, USA, 1997-2010
(2017)
While clean indoor air legislation at the state level is an evidence-based recommendation, only limited evidence exists regarding the impact of clean indoor air policies on state smoking prevalence. Using state smoking ...
The effects of elevated temperature and dissolved ρCO2 on a marine foundation species
(2017-04)
Understanding how climate change and other environmental stressors will affect species is a fundamental concern of modern ecology. Indeed, numerous studies have documented how climate stressors affect species distributions ...