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Transthyretin Aggregation Pathway toward the Formation of Distinct Cytotoxic Oligomers
(2019-01-10)
Characterization of small oligomers formed at an early stage of amyloid formation is critical to
understanding molecular mechanism of pathogenic aggregation process. Here we identifed and
characterized cytotoxic oligomeric ...
TOXIFY: a deep learning approach to classify animal venom proteins
(2019-06-28)
In the era of Next-Generation Sequencing and shotgun proteomics, the sequences
of animal toxigenic proteins are being generated at rates exceeding the pace of
traditional means for empirical toxicity verification. To ...
International Society of Sports Nutrition Position Stand: nutritional considerations for single-stage ultra-marathon training and racing
(2019-01-07)
In this Position Statement, the International Society of Sports Nutrition (ISSN) provides an objective and critical review of the literature pertinent to nutritional considerations for training and racing in single-stage ...
Overexpression of Long-Chain Acyl-CoA Synthetase 5 Increases Fatty Acid Oxidation and Free Radical Formation While Attenuating Insulin Signaling in Primary Human Skeletal Myotubes
(2019-03-31)
In rodent skeletal muscle, acyl-coenzyme A (CoA) synthetase 5 (ACSL-5) is suggested to localize to the mitochondria but its precise function in human skeletal muscle is unknown. The purpose of these studies was to define ...
Phase IIb, Randomized, Double-Blind Trial of GC4419 Versus Placebo to Reduce Severe Oral Mucositis Due to Concurrent Radiotherapy and Cisplatin For Head and Neck Cancer
(2019-12-01)
PURPOSE:
Oral mucositis (OM) remains a common, debilitating toxicity of radiation therapy (RT) for head and neck cancer. The goal of this phase IIb, multi-institutional, randomized, double-blind trial was to compare the ...
Polymorphisms in TNF Receptor Superfamily 1B (TNFRSF1B:rs3397) are Linked to Mycobacterium avium paratuberculosis Infection and Osteoporosis in Rheumatoid Arthritis
(2019-12-04)
We previously discovered that single nucleotide polymorphisms (SNPs) in PTPN2/22 (T-cell negative-regulators) occur in 78% of rheumatoid arthritis (RA), along with Mycobacterium avium paratuberculosis (MAP) infection in ...
Opinions on the Legitimacy of Death Declaration by Neurological Criteria from the Perspective of 3 Abrahamic Faiths
(2019-09-27)
Traditional criteria to identify death may not fit all circumstances. This manuscript explores religious jurisprudence to ascertain whether death declaration by neurological criteria (DDNC) is accepted as a valid by 3 ...
Using Gamification and Social Incentives to Increase Physical Activity and Related Social Cognition among Undergraduate Students in Shanghai, China
(2019-03-08)
Gamification and social incentives are promising strategies to increase the effectiveness of web-based physical activity (PA) interventions by improving engagement. In this study, we designed a PA intervention integrating ...
Variation in pigmentation gene expression is associated with distinct aposematic color morphs in the poison frog Dendrobates auratus
(2019-04-18)
Background:
Color and pattern phenotypes have clear implications for survival and reproduction in many species. However, the mechanisms that produce this coloration are still poorly characterized, especially at the genomic ...
Voluntary Restoration: Mitigation's Silent Partner in the Quest to Reverse Coastal Wetland Loss in the USA
(2019-08-28)
Coastal ecosystems are under pressure from a vast array of anthropogenic stressors, including development and climate change, resulting in significant habitat losses globally. Conservation policies are often implemented ...