Search
Now showing items 171-180 of 1119
PTEN status is a crucial determinant of the functional outcome of combined MEK and mTOR inhibition in cancer
(2017-02-21)
Combined MAPK/PI3K pathway inhibition represents an attractive, albeit toxic, therapeutic strategy
in oncology. Since PTEN lies at the intersection of these two pathways, we investigated whether PTEN status determines the ...
Real-time compression feedback for patients with in-hospital cardiac arrest: a multi-center randomized controlled clinical trial
(2019-01-03)
Objective: To determine if real-time compression feedback using a non-automated hand-held device improves
patient outcomes from in-hospital cardiac arrest (IHCA).
Methods: We conducted a prospective, randomized, controlled, ...
miRNA-36 inhibits KSHV, EBV, HSV-2 infection of cells via stifling expression of interferon induced transmembrane protein 1 (IFITM1)
(2017-12-21)
Kaposi’s sarcoma-associated herpesvirus (KSHV) is etiologically associated with all forms of Kaposi’s sarcoma worldwide. Little is currently known about the role of microRNAs (miRNAs) in KSHV entry.
We recently demonstrated ...
Refinement of risk stratification for childhood rhabdomyosarcoma using FOXO1 fusion status in addition to established clinical outcome predictors: A report from the Children's Oncology Group
(2019-08-06)
Background:
Previous studies of the prognostic importance of FOXO1 fusion status in patients with rhabdomyosarcoma (RMS) have had conflicting results. We re‐examined risk stratification by adding FOXO1 status to traditional ...
Regulation of cardiac fibroblast-mediated maladaptive ventricular remodeling by β-arrestins
(2019-07-03)
Cardiac fibroblasts (CF) play a critical role in post-infarction remodeling which can ultimately
lead to pathological fibrosis and heart failure. Recent evidence demonstrates that remote
(non-infarct) territory fibrosis ...
Reflection tomography of time-lapse GPR data for studying dynamic unsaturated flow phenomena
(2020-01-14)
Ground-penetrating radar (GPR) reflection tomography algorithms allow non-invasive monitoring of water
content changes resulting from flow in the vadose zone. The
approach requires multi-offset GPR data that are ...
Potential Mechanisms and Functions of Intermittent Neural Synchronization
(2017-05-30)
Neural synchronization is believed to play an important role in different brain functions. Synchrony in cortical and subcortical circuits is frequently variable in time and not perfect. Few long intervals of desynchronized ...
Position Paper From the Association of Pathology Chairs: Assessing Autopsy Competency in Pathology Residency Training
(2018-12-10)
Declining numbers of hospital autopsies performed in US pathology residency training programs and perceived declining practice of autopsy by many pathologists has caused stakeholder organizations to reassess the role of ...
Regulation of Skeletal Muscle Glucose Transport and Glucose Metabolism by Exercise Training
(2019-10-12)
Aerobic exercise training and resistance exercise training are both well-known for their ability to improve human health; especially in individuals with type 2 diabetes. However, there are critical differences between these ...
Pulmonary Exposure to Magnéli Phase Titanium Suboxides Results in Significant Macrophage Abnormalities and Decreased Lung Function
(2019-11-28)
Coal is one of the most abundant and economic sources for global energy production. However, the burning of coal is widely recognized as a significant contributor to atmospheric particulate matter linked to deleterious ...