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    Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review

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    Author
    Quinn, Joseph W.; Sewell, Kerry; Simmons, Dell E.
    Abstract
    Background: Healthcare-acquired hypernatremia (serum sodium >145 mEq/dL) is common among critically ill and other hospitalized patients and is usually treated with hypotonic fluid and/or diuretics to correct a “free water deficit.” However, many hypernatremic patients are eu- or hypervolemic, and an evolving body of literature emphasizes the importance of rapidly returning critically ill patients to a neutral fluid balance after resuscitation. Objective: We searched for any randomized- or observational-controlled studies evaluating the impact of active interventions intended to correct hypernatremia to eunatremia on any outcome in volume-resuscitated patients with shock and/or sepsis. Data sources: We performed a systematic literature search with studies identified by searching MEDLINE, Embase, Cochrane Central Register of Controlled Trials, Cochrane Database of Systematic Reviews, ClinicalTrials.gov, IndexCatalogue of the Library of the Surgeon General’s Office, DARE (Database of Reviews of Effects), and CINAHL and scanning reference lists of relevant articles with abstracts published in English. Data synthesis: We found no randomized- or observational-controlled trials measuring the impact of active correction of hypernatremia on any outcome in resuscitated patients. Conclusion: Recommendations for active correction of hypernatremia in resuscitated patients with sepsis or shock are unsupported by clinical research acceptable by modern evidence standards.
    URI
    http://hdl.handle.net/10342/6814
    Subject
     Hypernatremia; Sodium; Fluid therapy; Water-electrolyte imbalances; Critical illness; Shock 
    Date
    2018-03-21
    Citation:
    APA:
    Quinn, Joseph W., & Sewell, Kerry, & Simmons, Dell E.. (March 2018). Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review. Sage Open Medicine, (1-6. Retrieved from http://hdl.handle.net/10342/6814

    Display/Hide MLA, Chicago and APA citation formats.

    MLA:
    Quinn, Joseph W., and Sewell, Kerry, and Simmons, Dell E.. "Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review". Sage Open Medicine. . (1-6.), March 2018. March 04, 2021. http://hdl.handle.net/10342/6814.
    Chicago:
    Quinn, Joseph W. and Sewell, Kerry and Simmons, Dell E., "Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review," Sage Open Medicine 6, no. (March 2018), http://hdl.handle.net/10342/6814 (accessed March 04, 2021).
    AMA:
    Quinn, Joseph W., Sewell, Kerry, Simmons, Dell E.. Recommendations for active correction of hypernatremia in volume-resuscitated shock or sepsis patients should be taken with a grain of salt: A systematic review. Sage Open Medicine. March 2018; 6() 1-6. http://hdl.handle.net/10342/6814. Accessed March 04, 2021.
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    • 2017-2018 Open Access Publishing Fund
    • Emergency Med

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