Browsing Health Sciences Campus by Title
Now showing items 1476-1495 of 2639
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Lipid mediators of insulin resistance: ceramide signalling down-regulates GLUT4 gene transcription in 3T3-L1 adipocytes.
(East Carolina University, 1996-10-01)We have previously demonstrated that chronic exposure of 3T3- L1 adipocytes to tumour necrosis factor-α (TNF) resulted in a marked decrease (~90%) in cellular GLUT4 (insulin-responsive glucose transporter) mRNA content as ... -
A Literature Review and Development of Clinical Practice Guidelines for the Use and Disclosure of Herbal/Dietary Supplements in the Elderly Population
(2016-12-02)Background and Significance: There is an increased use of herbal and dietary supplements among the elderly population that has become a major phenomenon in primary care. Primary care providers must now address issues of ... -
The lived experience of nurse practitioner graduates' transition to hospital-based practice
(East Carolina University, 2010)The purpose of this hermeneutic phenomenology (van Manen, 1990) was to gain insight into the meaning and lived experience of nurse practitioners (NP) with at least one year of work experience regarding their initial ... -
LLL-3 inhibits STAT3 activity, suppresses glioblastoma cell growth and prolongs survival in a mouse glioblastoma model
(East Carolina University, 2009-01-13)Persistent activation of the signal transducer and activator of transcription 3 (STAT3) signalling has been linked to oncogenesis and the development of chemotherapy resistance in glioblastoma and other cancers. Inhibition ... -
LOCAL ADMINISTRATION OF CARBON MONOXIDE INHIBITS NEOINTIMA FORMATION IN BALLOON INJURED RAT CAROTID ARTERIES
(2005)Recent studies indicate that systemic induction of heme oxygenase-1 (HO-1), which oxidatively degrades heme into iron, biliverdin, and carbon monoxide (CO), or adenoviral-mediated gene transfer of HO-1 inhibits neointima ... -
Local Anesthetic Adjuvants Providing the Longest Duration of Analgesia for Single Injection Peripheral Nerve Blocks in Orthopedic Surgery: A Systematic Review
(2014-12-01)Inadequate pain relief after surgery may delay surgical recovery, decrease patient satisfaction, increase length of stay, increase hospital readmissions, and increase overall health care costs. One way to decrease postoperative ... -
Localization and Characterization of a 7.3-kDa Region of Caldesmon Which Reversibly Inhibits Actomyosin ATPase Activity
(East Carolina University, 1992-08-15)Cleavage of caldesmon with chymotrypsin yields a series of fragments which bind both calmodulin and actin and inhibit the binding of myosin subfragments to actin and the subsequent stimulation of ATPase activity. Several ... -
A Long Helix from the Central Region of Smooth Muscle Caldesmon
(East Carolina University, 1991-07-25)The central region of smooth muscle caldesmon is predicted to form α-helices on the basis of its primary structure. We have isolated a fragment (CT54) that contains this region. The hydrodynamic properties and the electron ... -
Long Noncoding RNA Expression Signatures of Metastatic Nasopharyngeal Carcinoma and Their Prognostic Value
(2015)Long noncoding RNAs (lncRNAs) have recently been found to play important roles in various cancer types. The elucidation of genome-wide lncRNA expression patterns in metastatic nasopharyngeal carcinoma (NPC) could reveal ... -
Long-term effect of insulin on glucose transport and insulin binding in cultured adipocytes from normal and obese humans with and without non-insulin-dependent diabetes.
(East Carolina University, 1987-10)We have tested the hypothesis that in vitro exposure of insulin- resistant adipocytes with insulin results in improved insulin action. A primary culture system of adipocytes from obese subjects with ... -
Long-Term Mortality of 306,868 Patients with Multi-Vessel Coronary Artery Disease: CABG versus PCI
(2013-08)Background Several randomized controlled trials (RCT) have reported no difference in long-term mortality between coronary artery bypass grafting (CABG) and percutaneous coronary intervention (PCI). The purpose of this ... -
Lots to know about benefits, risks of zinc
(2022-06-29)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is about use of zinc supplementation for covid and supporting the immune system. Discussed are some of the benefits and risks ... -
Low adenosine agent, composition, kit and method for treatment of airway disease
(1999-11-30)An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such ... -
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
(2000-02-24)A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, ... -
Low adenosine anti-sense oligonucleotide, compositions, kit and method for treatment of airway disorders associated with bronchoconstriction, lung inflammation, allergy(ies) and surfactant depletion
(2000-10-26)An in vivo method of selectively delivering a nucleic acid to a target gene or mRNA comprises the topical admistration, e.g. to the respiratory system, of a subject of a therapeutic amount of an oligonucleotide that is ...