Browsing Health Sciences Campus by Title
Now showing items 507-526 of 2643
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Cytotoxic activity of the novel small molecule AKT inhibitor SC66 in hepatocellular carcinoma cells
(2015-01)Hepatocellular carcinoma (HCC) is characterized by limited response to current drug therapies. Here, we report that SC66, a novel AKT inhibitor, reduced cell viability in a dose- and time-dependent manner, inhibited colony ... -
Daily walks can improve digestion, chronic conditions
(2023-09-13)This is a weekly Q and A newspaper column under the byline of Dr. Kathy Kolasa. Today's column is "Daily walks can improve digestion, chronic conditions." -
Dare County Quality Improvement Project for the Overweight and Obese Adult Patient
(2019-04-15)Obesity is a serious disease that has tripled in prevalence since the 1980s, it affects all Americans either directly or indirectly, and attributes to several serious comorbidities and premature death. While guidelines do ... -
DASH Diet Education for Improvement in Hypertensive Outcomes
(2020-04-30)Hypertension is a leading risk factor for cardiovascular disease (AHA, 2015). Although hypertension is a modifiable risk factor, 54% of an estimated one million adults with hypertension have poorly controlled hypertension ... -
Data-Related Support in U.S.-Based Health Sciences Libraries: An Analysis of AAHSL Member Sites
(2020-10-20)Scientific research is increasingly data-intensive, bringing with it new challenges related to the collection, analysis, storage, preservation, accessibility and communication of data. Federal funders, seeking to increase ... -
Deciphering the impact of fructose metabolism on liver mitochondrial bioenergetics
(East Carolina University, 2021-12-07)Since its discovery in 1980, the interest in nonalcoholic fatty liver disease, the liver manifestation of metabolic syndrome, has expanded due to the growing impact on the world's health. Commonly characterized by ... -
Decreasing Door-to-triage Times in the Emergency Department
(2023-07-14)In the emergency department, patients who are waiting for triage present with potentially time-sensitive and life-threatening conditions. The period of time between arrival and triage is rarely discussed in the literature, ... -
Decreasing Emergency Department Boarding Times for the Intensive Care Patient
(2021-07-19)When critically ill patients arrive in the ED, substantial resources are reallocated to the patient, moving the supplies and hospital personnel away from others. Critically ill patients are remaining in the ED waiting on ... -
Decreasing Employee Burnout Through Improved Resilience
(2022-07-25)Burnout rates for healthcare staff are continuing to rise at an alarming rate. Burnout can affect individual well-being, patient safety and satisfaction, quality of care delivered, and organizational costs. Improving staff ... -
Decreasing Falls in the Emergency Department
(2023-07-18)Decreasing falls in the Emergency Department (ED) is essential to protecting patient safety during the patient’s time in the ED. When a patient falls, it produces adverse effects contributing to poor patient outcomes. A ... -
Decreasing Inappropriate Speech Consults in a Neurologic Intensive Care Unit
(2022-07-18)Stroke-associated pneumonia (SAP) is a common post-stroke complication associated with an increased risk of hospital mortality, prolonged hospital stay, and associated healthcare costs. Nurses use bedside swallow screenings ... -
Defending Diversity: Affirmative Action and Medical Education
(East Carolina University, 1999-08)Affirmative action programs of all types are under attack legally and politically. Although medical schools have not been specifically targeted, their affirmative action programs, like others in higher education, are ... -
Deficiency of a Sinorhizobium meliloti bacA Mutant in Alfalfa Symbiosis Correlates with Alteration of the Cell Envelope
(East Carolina University, 2002-10)The BacA protein is essential for the long-term survival of Sinorhizobium meliloti and Brucella abortus within acidic compartments in plant and animal cells, respectively. Since both the S. meliloti and B. abortus bacA ... -
Deletion of the EphA2 receptor exacerbates myocardial injury and the progression of ischemic cardiomyopathy
(2014-04)EphrinA1-EphA-receptor signaling is protective during myocardial infarction (MI). The EphA2-receptor (EphA2-R) potentially mediates cardiomyocyte survival. To determine the role of the EphA2-R in acute non-reperfused ... -
DELINEATING THE MECHANISM OF AGGREGATE OR BIOFILM FORMATION IN THE LYME DISEASE SPIROCHETE BORRELIA BURGDORFERI
(East Carolina University, 2021-07-14)Borrelia burgdorferi, the spirochete causing Lyme disease, is transmitted to a vertebrate host by the bite of an infected Ixodes scapularis tick. The spirochete develops antibiotic resistance in humans likely due to the ... -
DELINEATING THE ROLE OF SOLUBLE CD25 AS AN IMMUNOREGULATORY MOLECULE THAT PROMOTES A LOW-ZONE IL-2 SIGNALING ENVIRONMENT FAVORABLE FOR THE SELECTION OF CD25HIGH FOXP3HIGH T CELLS
(East Carolina University, 2021-07-22)Autoimmune diseases develop due to the breakdown of tolerogenic mechanisms that normally maintain immune homeostasis. CD4+ CD25+ FOXP3+ regulatory T cells (Tregs) are critical in the maintenance of tolerance and the ...