Browsing Health Sciences Campus by Title
Now showing items 1290-1309 of 1574
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Role of central cannabinoid receptor GPR18 in cardiovascular regulation
(East Carolina University, 2014)The primary goal of this study was to characterize the role of GPR18 in the rostral ventrolateral medulla (RVLM) in blood pressure (BP) regulation and elucidate the mechanisms involved in central GPR18 mediated hypotensive ... -
Role of Inflammatory Microglia in Mediating Periadolescent Nicotine-Induced Reward Sensitization
(East Carolina University, 2018-07-23)Nicotine exposure during the onset of adolescence (periadolescence) is demonstrated to sensitize the brain to the rewarding effects of various drugs of abuse. Nicotine enhances the expression of the transcription factor ... -
The role of lexical and semantic access efficiency in predicting reading fluency in second and third grade children.
(East Carolina University, 2011)The present study investigated the role of lexical and semantic access efficiency in predicting reading fluency levels in 32 second and third grade students (16 second grade/16 third grade). In a series of lexical and ... -
The role of mediators of neuronal plasticity in the circadian regulation of suprachiasmatic nucleus by light
(East Carolina University, 2009)Circadian rhythms are highly conserved physiological functions that are present in almost all living organisms. In mammals, circadian rhythms are synchronized to the environmental light:dark cycle by daily adjustments in ... -
Role of neuronal nitric oxide in the regulation of vasopressin expression and release in response to inhibition of cathecholamine synthesis and dehydration
(East Carolina University, 2007-10-22)We used neuronal nitric oxide synthase (nNOS) gene knockout mice to study the effects of catecholamines and neuronal nitric oxide on vasopressin expression in the hypothalamic neurosecretory centers. nNOS gene deletion ... -
Role of nicotinic acetylcholine receptor subtypes α4β2 and α7 in nicotine-ethanol interaction and cross-tolerance: functional correlation with cerebellar nitric oxide
(East Carolina University, 2010)The prevalent co-abuse of alcohol and tobacco products results in higher morbidity and mortality rates than those caused by either drug alone, thus posing a serious health problem. Understanding the interactive relationship ... -
Role of Notch signaling in tumorigenesis, stemness, and epithelial to mesenchymal transtion in colorectal cancer.
(East Carolina University, 2015)Colorectal cancer is the third most commonly diagnosed cancer in both men and women in the United States. Surgical resection and combination chemotherapy are often used for treatment, but in later stages of the disease, ... -
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013)BACKGROUND: Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ... -
Role of the Iron Storage Ferritins Dps and DpsL during the Prolonged Oxidative Stress Response of Bacteroides fragilis
(East Carolina University, 2015-12-02)Bacteroides fragilis is a Gram negative anaerobe and member of the human intestinal tract microbiome. B. fragilis serves many beneficial roles within the intestinal tract; however, its translocation to the peritoneal cavity ... -
The role of the proximal small intestine in improvements in diabetes resolution and insulin sensitivity following bariatric surgery in type 2 diabetes
(East Carolina University, 2011)Bariatric surgery is an effective, rapid, and durable treatment for obesity and type 2 diabetes mellitus (T2DM). Roux-en Y Gastric Bypass (RYGB) resolves T2DM in 80% of cases, while gastric banding (LAGB) resolves T2DM in ... -
Roles of neutrophil gelatinase-associated lipocalin (NGAL) in human cancer
(2014-03)Cancer remains one of the major cause of death in the Western world. Although, it has been demonstrated that new therapies can improve the outcome of cancer patients, still many patients relapse after treatment. Therefore, ... -
Roles of the Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways in controlling growth and sensitivity to therapy-implications for cancer and aging
(2011-03)Dysregulated signaling through the Ras/Raf/MEK/ERK and PI3K/PTEN/Akt/mTOR pathways is often the result of genetic alterations in critical components in these pathways or upstream activators. Unrestricted cellular proliferation ... -
Roles of the RAF/MEK/ERK Pathway in Cell Growth, Malignant Transformation and Drug Resistance
(East Carolina University, 2007-08)Growth factors and mitogens use the Ras/Raf/MEK/ERK signaling cascade to transmit signals from their receptors to regulate gene expression and prevent apoptosis. Some components of these pathways are mutated or aberrantly ... -
The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding
(East Carolina University, 2008-02-22)The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ... -
S.O.S.
(2012-12)The concept that type 2 diabetes mellitus (T2DM) can be reversed with an intestinal operation is counterintuitive. How could our costliest disease be forced into full, durable, and safe remission with the bypass of a few ... -
Safe Handling of Mitomycin in the Perioperative Setting
(2021-04-27)Surgical intervention for glaucoma is slowly becoming more common. When a trabeculectomy is the surgical approach, Mitomycin-C, an antineoplastic agent, is often used to prevent surgical scarring. Standardization of ... -
Sarcoidosis activates diverse transcriptional programs in bronchoalveolar lavage cells
(2016-07-26)Abstract Background Sarcoidosis is a multisystem immuno-inflammatory disorder of unknown etiology that most commonly involves the lungs. We hypothesized that an unbiased ... -
Satiety inducing composition comprising Neuropeptide Y analogues and methods of inducing satiety and treating a disease or condition associated with it
(2002-07-30)Satiety inducing composition comprises Neuropeptide Y analogues which are effective for inducing satiety and for treating diseases and conditions associated with a lacking of, or having lowered, satiety. -
Schedule Distribution and Motor Learning Guided Treatment with Childhood Apraxia of Speech
(East Carolina University, 2011)The purpose of this study was to examine the use of motor learning guided (MLG) treatment with different treatment schedules in the treatment of participants with a diagnosis of childhood apraxia of speech (CAS). Five ...