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E-Cadherin negatively modulates delta-catenin-induced morphological changes and RhoA activity reduction by competing with p190RhoGEF for delta-catenin
(East Carolina University, 2008-12-12)
δ-Catenin is a member of the p120-catenin subfamily of armadillo proteins. Here, we describe
distinctive features of δ-catenin localization and its association with E-cadherin in HEK293 epithelial
cells. In HEK293 cells ...
What Is Good Nursing Care? The Lived Meaning of Quality Nursing Care for Practicing Nurses
(East Carolina University, 2008-04-11)
Healthcare quality in the United States of America (USA) is the subject of intense criticism. Although quality nursing care is vital to patient outcomes and safety, meaningful quality improvements have been disturbingly ...
A targeted Coch missense mutation: a knock-in mouse model for DFNA9 late-onset hearing loss and vestibular dysfunction
(East Carolina University, 2008-11-01)
Mutations in COCH (coagulation factor C homology) are etiologic for the late-onset, progressive, sensorineural hearing loss and vestibular dysfunction known as DFNA9. We introduced the G88E mutation by gene targeting into ...
Systemic Nutrition: What's YOUR Gut Reaction?
(East Carolina University, 2008)
Presentation accompanying lecture for receiving the Lenna Frances Cooper Award at the 2008 Food and Nutrition Conference and Exhibition of the American Dietetic Association
Otoconin-90 Deletion Leads to Imbalance but Normal Hearing: A Comparison with Other Otoconia Mutants
(East Carolina University, 2008-04)
Our sense of gravitation and linear acceleration is mediated by stimulation of vestibular hair cells through displacement of otoconia in the utricle and saccule (the gravity receptor organ). We recently showed that otoconin-90 ...
Peroxisome Proliferator-Activated Receptor-γ Regulates the Expression of Alveolar Macrophage Macrophage Colony- Stimulating Factor
(East Carolina University, 2008-07-01)
Macrophage CSF (M-CSF) regulates monocyte differentiation, activation, and foam cell formation. We have observed that it is elevated in human pulmonary alveolar proteinosis (PAP) and in the GMCSF knockout mouse, a murine ...
Bariatric Surgery: Risks and Rewards
(East Carolina University, 2008-11)
Context: Over 23 million Americans are afflicted with severe obesity, i.e. their body mass index (in
kilograms per square meter) values exceed 35. Of even greater concern is the association of the
adiposity with comorbidities ...
Physical Activity Levels of Patients Undergoing Bariatric Surgery in the Longitudinal Assessment of Bariatric Surgery (LABS) Study
(East Carolina University, 2008)
Background- Bariatric surgery candidates' physical activity (PA) level may contribute to the variability of weight loss and body composition changes following bariatric surgery. However, there is little research describing ...
Coronary Artery Calcium Scores: Current Thinking and Clinical Applications
(East Carolina University, 2008-09)
Most incident coronary disease occurs in previously asymptomatic individuals who were considered to be at a lower risk by traditional screening methods. There is a definite advantage if these individuals could be reclassified ...
The RXR-alpha C-terminus T462 is a NMR sensor for coactivator peptide binding
(East Carolina University, 2008-02-22)
The C-terminal activation function-2 (AF-2) helix plays a crucial role in retinoid X receptor alpha (RXRα)-mediated gene expression. Here, we report a nuclear magnetic resonance (NMR) study of the RXRα ligand-binding domain ...