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Now showing items 2551-2560 of 2687
Appraisal of uncertainty while waiting for a kidney transplant
(East Carolina University, 2012)
This study tested a middle range nursing theory to better understand the experience of uncertainty in deceased-donor kidney transplant candidates with a goal of identifying ways to improve the care of persons by nurses as ...
Investigations into the roles of bacteroides fragilis thioredoxins during the oxidative stress response
(East Carolina University, 2011)
The Gram-negative Bacteroides fragilis is the most frequently isolated bacterium from anaerobic infections. Native to the human intestinal tract, it serves a symbiotic role breaking down complex polysaccharides and ...
Essential Role of the Iron-Regulated Outer Membrane Receptor FauA in Alcaligin Siderophore-Mediated Iron Uptake in Bordetella Species
(East Carolina University, 1999-10)
Phenotypic analysis using heterologous host systems localized putative Bordetella pertussis ferric alcaligin transport genes and Fur-binding sequences to a 3.8-kb genetic region downstream from the alcR regulator gene. ...
Isolation and characterization of Bordetella bronchiseptica mutants deficient in siderophore activity.
(East Carolina University, 1993-02)
Iron acquisition by the gram-negative pathogens Bordetella bronchiseptica and Bordetella pertussis is thought to occur by hydroxamate siderophore-mediated transport as well as an apparently siderophore-independent process ...
The Redox-Sensitive Transcriptional Activator OxyR Regulates the Peroxide Response Regulon in the Obligate Anaerobe Bacteroides fragilis
(East Carolina University, 2000-09)
The peroxide response-inducible genes ahpCF, dps, and katB in the obligate anaerobe Bacteroides fragilis are
controlled by the redox-sensitive transcriptional activator OxyR. This is the first functional oxidative ...
Social communication between intellectually disabled, severe middle school students who use augmentative and alternative communication and their typically developing peers
(East Carolina University, 2013)
Augmentative and Alternative Communication (AAC) devices are often used as a mode of communication for people who cannot use spoken language to meet all of their communication needs. Current research is limited regarding ...
A two-component response regulator, gltR, is required for glucose transport activity in Pseudomonas aeruginosa PAO1.
(East Carolina University, 1996-10)
A 729-bp open reading frame (gltR) was identified in Pseudomonas aeruginosa PAO1 that encodes a product homologous to the two-component response regulator family of proteins. Disruption of gltR caused loss of glucose ...
Anti-cancer drug induced neurotoxicity and identification of Rho pathway signaling modulators as potential neuroprotectants
(East Carolina University, 2008-07)
Many chemotherapy drugs are known to cause significant clinical neurotoxicity, which can result in the early cessation of treatment. To identify and develop more effective means of neuroprotection it is important to ...
Anti-growth properties of BAY 41-2272 in vascular smooth muscle cells
(East Carolina University, 2009-02)
Vascular smooth muscle (VSM) growth is integral in the pathophysiology of blood vessel diseases, and identifying approaches that have capacity to regulate VSM growth is critically essential. Cyclic nucleotide signaling has ...
Amyloid-beta peptide A beta p3-42 affects early aggregation of full-length A beta 1-42
(East Carolina University, 2009-05)
The major amyloid beta (Aβ) peptides found in the brain of familial and late onset Alzheimer’s
disease include the full-length Aβ1-42 and N-terminally truncated, pyroglutamylated peptides
Aβp3-42 and Aβp11-42. The ...