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Oxytocin Modulation of Zebra Finch Vocal Development
(East Carolina University, 2010)
Autism spectrum disorder is associated with deficits in three main behavioral areas: social behaviors, repetitive behaviors, and language abnormalities. Accumulating evidence suggests a potential role for oxytocin signaling ...
Comparison of tolerance characteristics in the guinea pig following chronic in-vivo exposure to opioid versus cannabinoid receptor agonists
(East Carolina University, 2010)
Few studies have compared the nature of tolerance that develops following chronic in vivo opioid treatment with that which develops after chronic cannabinoid exposure in the same tissue and species. Based on similarities ...
Effects of Aerobic Capacity Phenotype on Adaptive Responses to Ischemic Stress
(East Carolina University, 2009)
Ischemic disease leads to increased tissue stress by decreasing supply of nutrients adequate to meet energy demands. To maintain functionality, compensatory mechanisms for diminished vascular supply are induced by numerous ...
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)
Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ...
Structural aging of the utricular macula in mice
(East Carolina University, 2012)
CBA/CaJ is a mouse strain that has no known genetic mutations affecting the inner ear, thereby serving as a control model for auditory and vestibular aging. C57BL/6J and CE/J mouse strains carry the genetic mutation ...
Generators of mammalian vestibular surface responses to head motion
(East Carolina University, 2012)
The linear vestibular sensory evoked potential (VsEP) is thought to be the compound electrical response of peripheral macular neurons and central neural relays, and as such used to directly assess macular function. The ...
Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)
The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ...
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)
The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ...
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)
Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...
Adenosine monophosphate-activated protein kinase inhibits vascular smooth muscle growth associated with vasculoproliferative disorders
(East Carolina University, 2013)
Vascular growth disorders are the major contributing factor to cardiovascular disease, the leading cause of morbidity and mortality worldwide. Aberrant vascular smooth muscle cell (VSMC) growth is a primary etiology ...