Browsing Brody School of Medicine by Issue Date
Now showing items 107-126 of 1484
-
Multiple target hybridizing nucleic acids, their preparation, compositions, formulation, kits and applications
(1999-03-25)Antisense oligonucleotides which bind to two or more RNA targets are disclosed. -
Method for the microbial decontamination of blood platelets
(1999-04-06)A method for inactivating microbiological contaminants in a human blood platelet preparation is disclosed. The method comprises, first, providing blood platelets, particularly human blood platelets, suspected of being ... -
Surgical aids containing pharmaceutically acceptable fixed-dried human blood platelets
(1999-05-11)Fixed-dried human blood platelets and processes for preparing them are disclosed. The platelets, upon reconstitution: adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change ... -
Premature mortality in the United States: the roles of geographic area, socioeconomic status, household type, and availability of medical care.
(East Carolina University, 1999-06)OBJECTIVES: This study examined premature mortality by county in the United States and assessed its association with metro/urban/rural geographic location, socioeconomic status, household type, and availability of medical ... -
Equitable rationing of highly specialised health care services for children: a perspective from South Africa.
(East Carolina University, 1999-06)The principles of equality and equity, respectively in the Bill of Rights and the white paper on health, provide the moral and legalfoundations forfuture health care for children in South Africa. However, given extreme ... -
Method of treatment using chemotherapy and erythropoietin
(1999-07-13)The use of human erythropoietin (EPO) to prevent or treat endothelial injury due to chemotherapy, radiation therapy, mechanical trauma, or to a disease state which damages the endothelium (such as inflammation, heart disease ... -
Defending Diversity: Affirmative Action and Medical Education
(East Carolina University, 1999-08)Affirmative action programs of all types are under attack legally and politically. Although medical schools have not been specifically targeted, their affirmative action programs, like others in higher education, are ... -
Quinolone signaling in the cell-to-cell communication system of Pseudomonas aeruginosa
(East Carolina University, 1999-09-28)Numerous species of bacteria use an elegant regulatory mechanism known as quorum sensing to control the expression of specific genes in a cell-density dependent manner. In Gram-negative bacteria, quorum sensing ... -
Essential Role of the Iron-Regulated Outer Membrane Receptor FauA in Alcaligin Siderophore-Mediated Iron Uptake in Bordetella Species
(East Carolina University, 1999-10)Phenotypic analysis using heterologous host systems localized putative Bordetella pertussis ferric alcaligin transport genes and Fur-binding sequences to a 3.8-kb genetic region downstream from the alcR regulator gene. ... -
Low adenosine agent, composition, kit and method for treatment of airway disease
(1999-11-30)An oligonucleotide which is antisense to a mRNA encoding a polypeptide involved in airway disease(s) contains up to three adenosines per every 21 nucleotide a method of treating airway disease in a subject in need of such ... -
Pharmaceutically acceptable fixed-dried human blood platelets
(1999-11-30)Fixed-dried human blood platelets and processes for preparing the same are disclosed. The platelets, upon reconstitution; adhere to thrombogenic surfaces; do not adhere to non-thrombogenic surfaces; undergo shape change ... -
Calponin interaction with alpha-actinin-actin: evidence for a structural role for calponin.
(East Carolina University, 1999-12)The purpose of this study was to address the paradox of calponin localization with a-actinin and filamin, two proteins with tandem calponin homology (CH) domains, by determining the effect of these proteins on the binding ... -
Systematic review of diagnostic tests for vaginal trichomoniasis.
(East Carolina University, 2000)Objective: To review critically and to summarize the evidence of diagnostic tests and culture media for the diagnosis of Trichomonas vaginitis. Methods: We performed a systematic review of literature indexed in MEDLINE of ... -
The Global Carbon Metabolism Regulator Crc Is a Component of a Signal Transduction Pathway Required for Biofilm Development by Pseudomonas aeruginosa
(East Carolina University, 2000-01)The transition from a planktonic (free-swimming) existence to growth attached to a surface in a biofilm occurs in response to environmental factors, including the availability of nutrients. We show that the catabolite ... -
Invasion and Intracellular Survival of Burkholderia cepacia
(East Carolina University, 2000-01)Burkholderia cepacia has emerged as an important pulmonary pathogen in immunocompromised patients and in patients with cystic fibrosis (CF). Little is known about the virulence factors and pathogenesis of B. cepacia, ... -
Crc Is Involved in Catabolite Repression Control of the bkd Operons of Pseudomonas putida and Pseudomonas aeruginosa
(East Carolina University, 2000-02)Crc (catabolite repression control) protein of Pseudomonas aeruginosa has shown to be involved in carbon regulation of several pathways. In this study, the role of Crc in catabolite repression control has been studied in ... -
Composition, kit and method for treatment of disorders associated withbronchoconstriction and lung inflammation
(2000-02-15)A method of reducing bronchoconstriction in a subject in need of suchtreatment is disclosed. The method comprises administering to the subject an Antisenseoligonucleotide molecule directed against the A.sub.1 or A.sub.3 ... -
Low adenosine anti-sense oligonucleotide agent, composition, kit and treatments
(2000-02-24)A composition comprises a nucleic acid comprising an oligo anti-sense to a target such as polypeptide(s) associated with an ailment afflicting lung airways, genes and mRNAs encoding them, genomic and mRNA flanking regions, ... -
Reporting and Concordance of Methodologic Criteria Between Abstracts and Articles in Diagnostic Test Studies
(East Carolina University, 2000-03)OBJECTIVE: To evaluate the quality and concordance of methodologic criteria in abstracts versus articles regarding the diagnosis of trichomoniasis. STUDY DESIGN: Survey of published literature. DATA SOURCES: ... -
Specific antisense oligonucleotide composition & method for treatment of disorders associated with bronchoconstriction and lung inflammation
(2000-03-21)A DNA comprises an oligonucleotide antisense to mRNA encoding an adenosine A.sub.1 or A.sub.3 receptor. The oligo is provided as a composition, various formulations, a capsule, and cartridge and in the form of a kit. The ...