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Peroxisome Proliferator-Activated Receptor Gamma Deficiency Promotes a T Lymphocyte Response in a Murine Model of Chronic Pulmonary Sarcoidosis
(East Carolina University, 2019-07-03)
Sarcoidosis is a chronic granulomatous disease of unknown etiology. Previous studies from our lab have shown a deficiency of the nuclear transcription factor peroxisome proliferator-activated receptor gamma (PPAR[gamma]) ...
Investigating the Role of Poxvirus Virulence Genes A35 and O1L in the Virus Life Cycle
(East Carolina University, 2019-07-22)
Poxviruses, some of the largest viruses in existence, have a great impact on the human and animal world due to their ability to infect a broad assortment of organisms and cause significant disease. Today, poxvirus infections ...
Neurovascular Mechanisms of Erectile Dysfunction Following Androgen Deprivation Therapy
(East Carolina University, 2019-12-20)
For nearly eight decades, androgen deprivation therapy (ADT) has been a common prostate cancer treatment. Although ADT increases the prostate cancer survival rate, urogenital side effects such as erectile dysfunction (ED) ...
Methods and Compositions for Poxvirus A35R Protein
(2012-11-22)
The present invention provides methods and compositions for modulating an immune response in a subject, comprising administering to the subject an effective amount of an A35R protein or active fragment thereof of vaccinia ...
NMR method for monitoring changes in the core of lipoprotein particles in metabolism and disease
(2017-01-14)
A method is disclosed for measuring the properties of protein and lipoprotein elements in a sample. The method includes the of placing a small volume of a sample into a NMR instrument tuned to measure a particular nucleus, ...
Emergency snake bite treatment devices, medical kits and related methods
(2014-02-04)
First aid or emergency snake bite treatment devices include a belt or other securing member attached to a compression (bite isolation) member, the compression member having an outwardly projecting wall that is configured ...
Methods of using carnosinol and analogs thereof
(2015-12-17)
Embodiments of the present invention relate to methods of preventing or treating diabetes, an obesity/diabetes-related condition, insulin sensitivity, heart disease, mitochondrial dysfunction or liver disease comprising ...
I want to survive and thrive: diet and physical activity recommendations for Breast Cancer Survivors
(2018-09)
In this article, we review current diet and physical activity recommendations for long-time survivors of breast cancer. We also hear the voice of a survivor and her response to the diagnosis of a postmenopausal breast ...
Development of small-molecule inhibitors of the initiating proteases, C1r and C1s, of the classical complement pathway
(East Carolina University, 2019-12-12)
Complement is a proteolytic cascade that upon activation plays a key effector role in the innate immune system and acts to prime the adaptive immune response. During normal homeostatic events, complement is tightly regulated ...