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The therapeutic potential of Rho GTPase intervention
(East Carolina University, 2013)
Small GTPases of the Rho family are well established regulators of critical cellular functions including cytoskeletal remodeling, motility, vesicle trafficking and cell cycle control. Additionally, aberrant signaling ...
Influence of carbon nanomaterial exposure on pro-constrictor mechanisms during pregnancy
(East Carolina University, 2013)
Engineered carbon based nanoparticles (CNP) such as fullerenes and multiwalled carbon nanotubes (MWCNTs) are increasingly used in industries and in nanomedicine as a platform for drug delivery. Following environmental/o ...
North Carolina's Plan to Address Obesity: Healthy Weight and Healthy Communities
(2013-02-07)
This presentation describes the 2013-2020 NC Obesity Plan. Evidence based core behaviors are described as well as strategies for encouraging the adoption of those behaviors in worksites, health care and colleges and ...
Genetic and hypoxic effects on germline tumor development in caenorhabditis elegans
(East Carolina University, 2013)
The process of differentiation of stem cells to committed, progenitor specific cell types is well studied but the reverse process of the dedifferentiation of these committed cells back to the undifferentiated state still ...
Creating Vidant Health's Healthy Food Environment
(2013-04)
The paper describes the journey taken by Vidant Health (formerly University Health Systems of Eastern Carolina) to create a healthy eating environmnet on its entire campus. Vidant Health was among the first hospitals in ...
The heart healthy lenoir project-an intervention to reduce disparities in hypertension control: study protocol
(2013)
Background
Racial disparities in blood pressure control are well established; however the impact of low health literacy (LHL) on blood pressure has garnered less attention. Office based interventions that are created with ...
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)
The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ...
Perfluorooctanoic acid-induced developmental cardiotoxicity in an avian model
(East Carolina University, 2013)
Perfluorooctanoic acid (PFOA) is a synthetic chemical used in polyfluormer production. It is a widespread environmental contaminant and is known to induce developmental toxicity in rodent models. As several related compounds ...
Disruption of mitochondrial fitness in human preadipocytes by fatty acids
(East Carolina University, 2013)
Adipose tissue lies at the core of energy metabolism, by not only releasing and taking up fatty acids (FA) according to the individuals overall surplus or deficit of energy, but also signaling other tissues to regulate ...