Search
Now showing items 11-20 of 34
Tissue Salvage in the Non-reperfused Myocardium Mediated by (the absence of the circadian rhythm gene) mPer2 and (the receptor tyrosine kinase) EphrinA1
(East Carolina University, 2010)
Alterations in circadian rhythm have been associated with numerous cardiovascular pathologies. In project 1, we tested the hypothesis that functional mutation of the Per2 circadian clock gene would provide cardioprotection ...
Vanadium pentoxide induces pulmonary inflammation and tumor promotion in a strain-dependent manner
(2010)
Background
Elevated levels of air pollution are associated with increased risk of lung cancer. Particulate matter (PM) contains transition metals that may potentiate neoplastic development through the induction of ...
Association of cardiac and vascular changes with ambient PMin diabetic individuals
(2010)
Background and Objective
Exposure to fine airborne particles (PM2.5) has been shown to be responsible for cardiovascular and hematological effects, especially in older people with cardiovascular disease. Some epidemiological ...
Metformin Improves Insulin Signaling in Obese Rats via Reduced IKK Action in a Fiber-Type Specific Manner
(2010)
Metformin is a widely used insulin-sensitizing drug, though its mechanisms are not fully understood. Metformin has been shown to activate AMPK in skeletal muscle; however, its effects on the inhibitor of κB kinaseβ (IKKβ) ...
Expression of a protein involved in bone resorption, Dkk1, is activated by HTLV-1 bZIP factor through its activation domain
(2010)
Background
Human T-cell leukemia virus type 1 (HTLV-1) is the etiologic agent of adult T-cell leukemia, a malignancy characterized by uncontrolled proliferation of virally-infected CD4+ T-cells. Hypercalcemia and bone ...
Acute Adverse Effects of Fine Particulate Air Pollution on Ventricular Repolarization
(2010-07)
Background
The mechanisms for the relationship between particulate pollution and cardiac disease are not fully understood.
Objective
We examined the effects and time course of exposure to fine particulate matter ≤ 2.5 ...
Outcomes of Roux-en-Y gastric bypass surgery for severely obese patients with type 1 diabetes: a case series report
(2010)
Roux-en-Y gastric bypass surgery (RYGB) reverses type 2 diabetes (DM2) in approximately 83% of patients with morbid or severe obesity. This procedure has been performed in small numbers of severely obese patients with type ...
Multiple Translation Factor eIF4G (IFG-1) Isoforms are Required for the Apoptosome-Dependent Activation of Germ Cell Apoptosis
(East Carolina University, 2010)
Apoptosis is a naturally occurring process during animal development required for the programmed killing and removal of injured cells. Cellular insult induces a switch in translation that allows for the rapid synthesis ...
Post-Transcriptional Regulation of mRNA Metabolism during Differentiation of 3T3-L1 Cells: Role of HuR
(East Carolina University, 2010)
Our studies address early control points in the differentiation process that are necessary for expression as well as the maintenance of the adipocyte phenotype. We have focused on the post-transcriptional regulation of ...