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Now showing items 181-190 of 1484
THERAPEUTIC AND TOXICOLOGICAL EVALUATION OF BROAD-SPECTRUM ANTIMICROBIAL TRICLOSAN AS A CHEMOTHERAPEUTIC AGENT
(East Carolina University, 2019-05-07)
Triclosan (TCS) is a phenolic antimicrobial incorporated in personal care products and medical devices. Interest in the antiproliferative properties of TCS has recently grown owing to its antilipogenic effects. Through the ...
Docosahexaenoic acid-derived metabolites target the B-cell driven immune response in obese mice
(East Carolina University, 2019-06-07)
Obesity is associated with an impaired humoral immune response. As B cells mediate the humoral immune response, they are major cellular targets in diet induced obesity models. Several studies have established that B cell ...
The C-terminus of Troponin T Modulates Calcium Regulation of Actin-Myosin Interactions
(East Carolina University, 2019-05-02)
The highly conserved terminal fourteen C-terminal residues of troponin T play a novel role in the regulation of striated muscle contraction. Elimination of the terminal fourteen residues of the C-terminal region of troponin ...
OPPOSING PERSISTENT BEHAVIORAL EFFECTS OF PHYTO- AND ENDOCANNABINOIDS FOLLOWING CHRONIC DEVELOPMENTAL, BUT NOT ADULT, TREATMENTS
(East Carolina University, 2019-04-23)
The rate of adolescent Cannabis abuse is increasing for recreational purposes and it is thought to be linked to a range of developmental and social problems. Many studies have demonstrated effects of early Cannabis exposure ...
Catecholamine metabolism via monoamine oxidase (MAO) within myocardium of individuals with type 2 diabetes
(East Carolina University, 2019-04-23)
The primary comorbidity and cause of mortality in type 2 diabetes is cardiovascular disease. The structural and the functional cardiac remodeling observed in patients with type 2 diabetes has been shown to be driven by a ...
DISCRIMINATING BETWEEN CARDIOLIPIN CONCENTRATION AND ACYL CHAIN COMPOSITION ON MEMBRANE BIOPHYSICAL ORGANIZATION
(East Carolina University, 2018-11-28)
The pathogenesis of cardiovascular diseases (CVDs) is driven, in part, from impairment in myocardial energy metabolism. There is convincing evidence that myocardial metabolic abnormalities are fundamentally driven by ...
Macrophage Regulation in the Murine Inflammatory Response
(East Carolina University, 2018-08-30)
The development of acute and chronic liver disease is a complex condition involving the dysregulation of hepatic metabolism and the accumulation of critical immune cells; specifically, the recruitment and activation of ...
The Role of Differential Sensitivity to Retinoic Acid (RA) in Regulating Spermatogonial Fate
(East Carolina University, 2018-12-10)
In the mammalian testis, the foundation of spermatogenesis is provided by spermatogonial stem cells (SSCs); their progeny either remain as stem cells (following a self-renewal division) or proliferate as undifferentiated ...
The Impact of Online Video Cases on Clinical Reasoning in Occupational Therapy Education: A Quantitative Analysis
(2018-07-01)
Clinical reasoning, the cognitive process of a skilled occupational therapist, is a complex and necessary component of evaluating clients and implementing interventions that facilitate each client’s achievement of relevant ...
Anatomical-Molecular Distribution of EphrinA1 in Infarcted Mouse Heart Using MALDI Mass Spectrometry Imaging
(2018-01-05)
EphrinA1 is a tyrosine kinase receptor localized in the cellular membrane of healthy cardiomyocytes, the expression of which is lost upon myocardial infarction (MI). Intra-cardiac injection of the recombinant form of ...