Search
Now showing items 241-250 of 1484
Dopaminergic modulation of the autonomic nervous system: in vitro and in vivo evidence from the mouse
(East Carolina University, 2012)
Central nervous system (CNS) function depends on both the connections between the underlying neurons and neural circuits and their activity. Neuronal activity in turn can be classified as neurotransmission and neuromodulation, ...
Reporting and Concordance of Methodologic Criteria Between Abstracts and Articles in Diagnostic Test Studies
(East Carolina University, 2000-03)
OBJECTIVE: To evaluate the quality and concordance of methodologic criteria in abstracts versus articles regarding the diagnosis of trichomoniasis.
STUDY DESIGN: Survey of published literature.
DATA SOURCES: ...
Activation of the proton sensing G-protein coupled receptor, GPR4, regulates focal adhesion dynamics and delays cell spreading due to increased cytoskeletal tension
(East Carolina University, 2013)
The tumor microenvironment is characteristically acidic due to insufficient blood perfusion, chronic inflammation, hypoxia, and altered cell metabolism. The low pH found in the tumor microenvironment may facilitate the ...
The effect of brevenal on brevetoxin-induced DNA damage in human lymphocytes
(East Carolina University, 2005-11)
Brevenal is a nontoxic short-chain trans-syn polyether that competes with brevetoxin (PbTx) for the active site on voltage-sensitive sodium channels. The PbTxs are highly potent polyether toxins produced during blooms of ...
Molecular mechanisms of TMEFF2 action in Prostate Cancer
(East Carolina University, 2013)
The transmembrane protein with epidermal growth factor and two follistatin motifs 2 (TMEFF2) is an evolutionarily conserved type I transmembrane protein expressed in the embryo and limited adult tissues, mainly the brain ...
Apigenin prevents chemically-induced skin tumor formation and inhibits COX-2 expression and activity in SKH-1 mouse epidermis
(East Carolina University, 2012)
The most common type of cancer in the United States is non-melanoma skin cancer (NMSC), with an estimated two million new cases diagnosed each year. Numerous malignancies including NMSC, colon, breast, and prostate cancer ...
VACCINIA VIRUS O1L VIRULENCE GENE AND PROTEIN LOCALIZATION
(2015)
Smallpox killed an estimated 500 million people in the twentieth century alone. Although this fatal disease was eradicated from the world over thirty years ago, its potential use as a bioterrorism agent remains a concern. ...
The extracellular processing of aggrecan aggregate and its effect on CD44 mediated internalization of hyaluronan.
(East Carolina University, 2015)
In many cells the hyaluronan receptor CD44 mediates the endocytosis of hyaluronan and its delivery to endosomes / lysosomes. The regulation of this process remains largely unknown. In most extracellular matrices hyaluronan ...
Relationship Between Cardiovascular Disease Risk and Fast Food Consumption in Undergraduate Honors College Students
(2014)
College students are often pushed towards fast foods as a means of getting a pleasurable, quick bite to eat. Fast foods are high in fat, salt, and sugar content and can lead to cardiovascular disease(CVD) risk. Honors ...
Fesselin, an intrinsically disordered smooth muscle protein, organizes and stabilizes actin-myosin and myosin
(East Carolina University, 2014)
Fesselin is an intrinsically disordered protein that is known to bind a large variety of cytoskeletal proteins. The proteins fesselin is known to bind include: actin (Leinweber et al. 1999), [alpha]-actinin (Pham et al. ...