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The Combined Influence of Oral Contraceptives and Human Papillomavirus Virus on Cutaneous Squamous Cell Carcinoma
(2011-03)
The vast majority of cutaneous squamous cell carcinoma (CSCC) will occur in those with fair complexion, tendency to burn, and high ultraviolet radiation (UVR) exposure. Organ transplant recipients also are an important ...
EPG5-related Vici syndrome: a paradigm of neurodevelopmental disorders with defective autophagy
(2016-03)
Vici syndrome is a progressive neurodevelopmental multisystem disorder due to recessive mutations in the key autophagy gene EPG5. We report genetic, clinical, neuroradiological, and neuropathological features of 50 children ...
Differentiation-dependent Requirement of Tsix long non-coding RNA in Imprinted X-chromosome Inactivation
(2014-06)
Imprinted X-inactivation is a paradigm of mammalian transgenerational epigenetic regulation resulting in silencing of genes on the paternally-inherited X-chromosome. The pre-programmed fate of the X-chromosomes is thought ...
Patient and Practice Perspectives on Strategies for Controlling Blood Pressure, North Carolina, 2010–2012
(2014)
Introduction
Patient and practice perspectives can inform development of team-based approaches to improving blood pressure control in primary care. We used a community-based participatory research approach to assess patient ...
Carbon Nanotube-Induced Pulmonary Granulomatous Disease: 1 and Alveolar Macrophage M1 Activation
(2013-12)
Sarcoidosis, a chronic granulomatous disease of unknown cause, has been linked to several environmental risk factors, among which are some that may favor carbon nanotube formation. Using gene array data, we initially ...
Alveolar macrophages of GM-CSF knockout mice exhibit mixed M1 and M2 phenotypes
(2013)
Background
Activin A is a pleiotrophic regulatory cytokine, the ablation of which is neonatal lethal. Healthy human alveolar macrophages (AMs) constitutively express activin A, but AMs of patients with pulmonary alveolar ...
HIV Screening and Awareness Survey for Pregnant Women in a Remote Area in Xinjiang Uyghur Autonomous Region of China
(2011-11)
Objective:
The number of people infected with human immunodeficiency virus (HIV) in China has increased in recent years. HIV screening for pregnant women was performed in a remote area in Xinjiang, as an effort to promote ...
Effects of robotic-assisted laparoscopic prostatectomy on surgical pathology specimens
(2012)
Background
Robotic-assisted laparoscopic prostatectomy (RALP) has greatly changed clinical management of prostate cancer. It is important for pathologists and urologists to compare RALP with conventional open radical ...
VZV in biopsy-positive and -negative giant cell arteritis: Analysis of 100+ temporal arteries
(2016-03)
Objective:
Varicella-zoster virus (VZV) infection may trigger the inflammatory cascade that characterizes giant cell arteritis (GCA).
Methods:
Formalin-fixed, paraffin-embedded GCA-positive temporal artery (TA) biopsies ...
Activation of GPR4 by Acidosis Increases Endothelial Cell Adhesion through the cAMP/Epac Pathway
(2011)
Endothelium-leukocyte interaction is critical for inflammatory responses. Whereas the tissue microenvironments are often acidic at inflammatory sites, the mechanisms by which cells respond to acidosis are not well understood. ...