Browsing Open Access by Title
Now showing items 775-794 of 866
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Susceptibility and Antibody Response of the Laboratory Model Zebra Finch (Taeniopygia guttata) to West Nile Virus
(2017-01-03)Since the introduction of West Nile virus (WNV) into North America in 1999 a number of pas- serine bird species have been found to play a role in the amplification of the virus. Arbovirus surveillance, observational studies ... -
Synchronized Beta-Band Oscillations in a Model of the Globus Pallidus - Subthalamic Nucleus Network under External Input
(2016)Hypokinetic symptoms of Parkinson’s disease are usually associated with the excessively strong oscillations and synchrony in the beta frequency band. The origin of this synchronized oscillatory dynamics is being debated. ... -
A systematic mRNA control mechanism for germline stem cell homeostasis and cell fate specification
(2016-02)Germline stem cells (GSCs) are the best understood adult stem cell types in the nematode Caenorhabditis elegans, and have provided an important model system for studying stem cells and their cell fate in vivo, in mammals. ... -
A system‐based intervention to reduce Black‐White disparities in the treatment of early stage lung cancer: A pragmatic trial at five cancer centers
(2019-01-11)Background: Advances in early diagnosis and curative treatment have reduced high mortality rates associated with non‐small cell lung cancer. However, racial disparity in survival persists partly because Black patients ... -
Targeted therapy for hepatocellular carcinoma: Novel agents on the horizon
(2012-03-31)Hepatocellular carcinoma (HCC) is the most common liver cancer, accounting for 90% of primary liver cancers. In the last decade it has become one of the most frequently occurring tumors worldwide and is also considered to ... -
Targeting signaling and apoptotic pathways involved in chemotherapeutic drug-resistance of hematopoietic cells
(2017-08-24)A critical problem in leukemia as well as other cancer therapies is the development of chemotherapeutic drug-resistance. We have developed models of hematopoietic drug resistance that are based on expression of dominant-negative ... -
TEAM-UP for quality: a cluster randomized controlled trial protocol focused on preventing pressure ulcers through repositioning frequency and precipitating factors
(2018-02-20)Background: Pressure ulcers/injuries (PrUs), a critical concern for nursing homes (NH), are responsible for chronic wounds, amputations, septic infections, and premature deaths. PrUs occur most commonly in older adults and ... -
Telephone surveys underestimate cigarette smoking among African-Americans
(2013-09-25)Background. This study tested the hypothesis that data from random digit-dial telephone surveys underestimate the prevalence of cigarette smoking among African-American adults. Method. A novel, community-sampling method ... -
Temperature Influences Herbivory and Algal Biomass in the Galápagos Islands
(2018-08-17)Temperature can influence trophic interactions via predictable effects on the metabolism of ecothermic consumers. Under some conditions, warming should increase top–down control, and trophic transfer rates, leading to ... -
Temporal Association Between Ischemic Muscle Perfusion Recovery and the Restoration of Muscle Contractile Function After Hindlimb Ischemia
(2019-06-28)During incomplete skeletal muscle recovery from ischemia, such as that occurs with critical limb ischemia, the temporal relationship between recovery of muscle capillary perfusion and contractile function is poorly defined. ... -
Temporal dynamics of genetic clines of invasive European green crab (Carcinus maenas) in eastern North America
(2018-06-08)Two genetically distinct lineages of European green crabs (Carcinus maenas) were in- dependently introduced to eastern North America, the first in the early 19th century and the second in the late 20th century. These ... -
Testing for selection on color and pattern in a mimetic radiation
(2012-08-01)In this paper, we analyze variation in spectral reflectance and color pattern among populations to demonstrate dramatic divergence between four distinct morphs of the mimic poison frog Ranitomeya imitator. We also analyze ... -
Testing the Duke Population Health Profile (Duke-PH) in a Sample of Community Health Center Patients
(2019-09-04)Introduction: Our purpose was to develop and test a brief, self-report, and scorable survey instrument for measuring population health profiles from the individual respondent's perspective. We defined population health as ... -
“Their Packaging Has Always Been Like a Power”: A Qualitative Study of U.S. Smokers’ Perceptions of Cigarette Pack Visual Design Features to Inform Product Regulation
(2017-10-17)Cigarette packaging matters to consumer behavior. However, it is less clear which changes to packaging design would be salient for adult smokers. Such information is critically important to regulators in the United States ... -
Theoretical aspects and modelling of cellular decision making, cell killing and information-processing in photodynamic therapy of cancer
(2013-09-03)Background: The aim of this report is to provide a mathematical model of the mechanism for making binary fate decisions about cell death or survival, during and after Photodynamic Therapy (PDT) treatment, and to supply the ... -
Therapeutic targeting of CK2 in acute and chronic leukemias
(2018-01)Phosphorylation can regulate almost every property of a protein and is involved in all fundamental cellular processes. Thus, proper regulation of phosphorylation events is critical to the homeostatic functions of cell ... -
Therapeutic Targeting of mTOR in T-Cell Acute Lymphoblastic Leukemia: An Update
(2018-06-26)T-cell acute lymphoblastic leukemia (T-ALL) is an aggressive blood malignancy that arises from the clonal expansion of transformed T-cell precursors. Although T-ALL prognosis has significantly improved due to the development ... -
Time course metabolome of Roux-en-Y gastric bypass confirms correlation between leptin, body weight and the microbiome
(2018-05-31)Roux-en-Y gastric bypass (RYGB) is an effective way to lose weight and reverse type 2 dia- betes. We profiled the metabolome of 18 obese patients (nine euglycemic and nine diabet- ics) that underwent RYGB surgery and seven ... -
Time course of altered sensitivity to inhibitory and excitatory agonist responses in the longitudinal muscle-myenteric plexus and analgesia in the guinea pig after chronic morphine treatment
(2012-01-10)Tolerance that develops after chronic morphine exposure has been proposed to be an adaptive response that develops and decays over a defined time course. The present study examined the development of tolerance to the acute ...