Browsing Open Access by Author "Sanderlin, Edward J."
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Contextual tumor suppressor function of T cell death-associated gene 8 (TDAG8) in hematological malignancies
Justus, Calvin R.; Sanderlin, Edward J.; Dong, Lixue; Sun, Tianai; Chi, Jen-Tsan; Lertpiriyapong, Kvin; Yang, Li V. (2017-12)Background: Extracellular acidosis is a condition found within the tumor microenvironment due to inadequate blood perfusion, hypoxia, and altered tumor cell metabolism. Acidosis has pleiotropic effects on malignant progres‐ ... -
Molecular Connections between Cancer Cell Metabolism and the Tumor Microenvironment
Calvin, Justin R.; Sanderlin, Edward J.; Yang, Li V. (2015)Cancer cells preferentially utilize glycolysis, instead of oxidative phosphorylation, for metabolism even in the presence of oxygen. This phenomenon of aerobic glycolysis, referred to as the “Warburg effect”, commonly ... -
The Proton-Sensing GPR4 Receptor Regulates Paracellular Gap Formation and Permeability of Vascular Endothelial Cells
Krewson, Elizabeth A.; Sanderlin, Edward J.; Marie, Mona A.; Akhtar, Shayan Nik; Velcicky, Juraj; Loetscher, Pius; Yang, Li V. (2020-02-21)be activated by protons in the inflamed tissue microenvironment. Herein, we report that acidosis-induced GPR4 activation increases paracellular gap formation and permeability of vascular endothelialcells through the ...