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Substrate utilization during submaximal exercise in children with a severely obese parent
(2012-05-09)
Background
We have reported a reduction in fatty acid oxidation (FAO) at the whole-body level and in skeletal muscle in severely obese (BMI ≥ 40 kg/m2) individuals; this defect is retained in cell culture suggesting an ...
Stressing the heart of the matter: Re-thinking the mechanisms underlying therapeutic effects of n-3 polyunsaturated fatty acids
(2012-07-02)
Despite their clear therapeutic effects in coronary heart disease, use of n-3 polyunsaturated fatty acids (PUFAs) to treat other types of cardiovascular disease remains controversial, and serious obstacles exist in ...
Rituximab therapy in pulmonary alveolar proteinosis improves alveolar macrophage lipid homeostasis
(2012-06-14)
Pulmonary Alveolar Proteinosis (PAP) patients exhibit an acquired deficiency of biologically active granulocyte-macrophage colony stimulating factor (GM-CSF) attributable to GM-CSF specific autoantibodies. PAP alveolar ...
Two hits are better than one: Targeting both phosphatidylinositol 3-kinase and mammalian target of rapamycin as a therapeutic strategy for acute leukemia treatment
(2012-05-04)
Phosphatidylinositol 3-kinase (PI3K) and mammalian target of rapamycin (mTOR) are two key components of the PI3K/Akt/mTOR signaling pathway. This signal transduction cascade regulates a wide range of physiological cell ...
Metagenomic Evidence for H2 Oxidation and H2 Production by Serpentinite-Hosted Subsurface Microbial Communities
(2012-01-06)
Among civilian academic physicians, having a mentor is associated with greater job satisfaction. Whether this is true for military physicians is unknown. We sought to examine whether having a mentor is associated with ...
Measures of the consumer food store environment: A systematic review of the evidence 2000-2011
(2012-08)
Description of the consumer food environment has proliferated in publication. However, there has been a lack of systematic reviews focusing on how the consumer food environment is associated with the following: (1) ...
Estimating coastal lagoon tidal flooding and repletion with multidate ASTER thermal imagery
(2012-10-18)
Coastal lagoons mix inflowing freshwater and tidal marine waters in complex spatial patterns. This project sought to detect and measure temperature and spatial variability of flood tides for a constricted coastal lagoon ...
In Vivo Blood Glucose Quantification Using Raman Spectroscopy
(2012-10-25)
We here propose a novel Raman spectroscopy method that permits the noninvasive measurement of blood glucose concentration. To reduce the effects of the strong background signals produced by surrounding tissue and to obtain ...
Factors associated with survival of veterans with gastrointestinal neuroendocrine tumors
(2012-05-27)
Background. Gastrointestinal (GI) neuroendocrine tumor (NET) incidence has been increasing; however, GI NET within the national Veterans Affairs (VA) health system has not been described. Methods. We used the VA Central ...