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Tophus burden reduction with pegloticase: Results from phase 3 randomized trials and open-label extension in patients with chronic gout refractory to conventional therapy
(2013-09-26)
Introduction
Two replicate randomized, placebo-controlled six-month trials (RCTs) and an open-label treatment extension (OLE) comprised the pegloticase development program in patients with gout refractory to conventional ...
Yttrium-90 radioembolization in patients with hepatocellular carcinoma who have previously received sorafenib
(2013-12-30)
Purpose: Ytrrium-90 radioembolization (RE) is a locoregional therapy option for hepatocellular carcinoma (HCC). Sorafenib is a multikinase inhibitor used in HCC that can potentially affect the efficacy of RE by altering ...
Ordinal-Level Phylogenomics of the Arthropod Class Diplopoda (Millipedes) Based on an Analysis of 221 Nuclear Protein-Coding Loci Generated Using Next-Generation Sequence Analyses
(2013-11-13)
BACKGROUND: The ancient and diverse, yet understudied arthropod class Diplopoda, the millipedes, has a muddled taxonomic history. Despite having a cosmopolitan distribution and a number of unique and interesting characteristics, ...
The scale and evolutionary significance of horizontal gene transfer in the choanoflagellate Monosiga brevicollis
(2013-10)
It is generally agreed that horizontal gene transfer (HGT) is common in phagotrophic protists. However, the overall scale of HGT and the cumulative impact of acquired genes on the evolution of these organisms remain largely ...
The Transcriptional Regulator Np20 Is the Zinc Uptake Regulator in Pseudomonas aeruginosa
(2013-09-23)
Zinc is essential for all bacteria, but excess amounts of the metal can have toxic effects. To address this, bacteria have developed tightly regulated zinc uptake systems, such as the ZnuABC zinc transporter which is ...
The role of PPARγ in carbon nanotube-elicited granulomatous lung inflammation
(2013-01-23)
Background
Although granulomatous inflammation is a central feature of many disease processes, cellular mechanisms of granuloma formation and persistence are poorly understood. Carbon nanoparticles, which can be products ...
The effect of race and chronic obstructive pulmonary disease on long-term survival after coronary artery bypass grafting
(2013-04)
Background: Chronic obstructive pulmonary disease (COPD) is a known predictor of decreased long-term survival after coronary artery bypass grafting (CABG). Differences in survival by race have not been examined.
Methods: ...
Expression of Bacteroides fragilis hemolysins in vivo and role of HlyBA in an intra-abdominal infection model
(2013-02-26)
Bacteroides fragilis is the most frequent opportunistic pathogen isolated from anaerobic infections. However, there is a paucity of information regarding the genetic and molecular aspects of gene expression of its virulence ...
Establishment of the Coast Range ophiolite microbial observatory (CROMO): Drilling objectives and preliminary outcomes
(2013-11-05)
Abstract. This project aimed to establish a subsurface microbial observatory in ultramafic rocks, by drilling into an actively serpentinizing peridotite body, characterizing cored rocks, and outfitting the boreholes for a ...
Food venue choice, consumer food environment, but not food venue availability within daily travel patterns are associated with dietary intake among adults, Lexington Kentucky 2011
(2013-01-29)
The retail food environment may be one important determinant of dietary intake. However, limited research focuses on individuals' food shopping behavior and activity within the retail food environment. This study's aims ...