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Healthy CD4+ T lymphocytes are not affected by targeted therapies against the PI3K/Akt/mTOR pathway in T-cell acute lymphoblastic leukemia
(2016-08-01)
An attractive molecular target for novel anti-cancer therapies is the
phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR)
pathway which is commonly deregulated in many types of cancer. Nevertheless, ...
Murine mesothelin: characterization, expression, and inhibition of tumor growth in a murine model of pancreatic cancer
(2016)
Background: Mesothelin has attracted much interest as a tumor specific antigen; it has been reported to promote
tumor development and to be a good target for cancer treatment. Most studies to date have used human
mesothelin ...
Medicare Under Age 65 and Medicaid Patients Have Poorer Bowel Preparations: Implications for Recommendations for an Early Repeat Colonoscopy
(2016-05-17)
Colonoscopy is performed on patients across a broad spectrum of demographic characteristics. These characteristics may aggregate by patient insurance provider and influence
bowel preparation quality and the prevalence of ...
Predominant Expression of Hybrid N-Glycans Has Distinct Cellular Roles Relative to Complex and Oligomannose N-Glycans
(2016-06)
Glycosylation modulates growth, maintenance, and stress signaling processes.
Consequently, altered N-glycosylation is associated with reduced fitness and disease. Therefore,
expanding our understanding of N-glycans in ...
Probing the Kinetic Anabolism of Poly-Beta-Hydroxybutyrate in Cupriavidus necator H16 Using Single-Cell Raman Spectroscopy
(2016-08)
Poly-beta-hydroxybutyrate (PHB) can be formed in large amounts in Cupriavidus necator and is important for the industrial production of biodegradable plastics. In this investigation, laser tweezers Raman spectroscopy (LTRS) ...
Response and resilience of Spartina alterniflora to sudden dieback
(2016-08)
We measured an array of biophysical and spectral variables to evaluate the response and recovery of Spartina alterniflora to a sudden dieback event in spring and summer 2004 within a low marsh in coastal Virginia, USA. S. ...
Rapid Evolution of Manifold CRISPR Systems for Plant Genome Editing
(2016-11-14)
Advanced CRISPR-Cas9 based technologies first validated in mammalian cell systems
are quickly being adapted for use in plants. These new technologies increase
CRISPR-Cas9’s utility and effectiveness by diversifying ...
Quantitative assessment of image motion blur in diffraction images of moving biological cells
(2016-02)
Motion blur (MB) presents a significant challenge for obtaining high-contrast image data from biological cells with a polarization diffraction imaging flow cytometry (p-DIFC) method. A new p-DIFC experimental system has ...
Genetic Architecture of Conspicuous Red Ornaments in Female Threespine Stickleback
(2016)
Explaining the presence of conspicuous female ornaments that take the form of male-typical traits has been a longstanding challenge in evolutionary biology. Such female ornaments have been proposed to evolve via both ...